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Background: Human behaviours have been classified in domains such as health, occupation and sustainability. We aimed to develop a broadly applicable behavioural framework to facilitate integrating evidence across domains.
Methods: The Human Behaviour Ontology (HBO), a part of the Behaviour Change Intervention Ontology (BCIO), was developed by: (1) specifying its scope, (2) identifying candidate classes from existing classifications, (3) refining it by annotating behaviours in relevant literature, (4) a stakeholder review with behavioural and ontology experts, (5) testing the inter-rater reliability of its use in annotating research reports, (6) refining classes and their relations, (7) reviewing its coverage of behaviours in theories and (8) publishing its computer-readable version.
Results: The initial ontology contained 128 classes (Steps 1-4), achieving an inter-rater reliability of 0.63 for familiar researchers and 0.74 after minor adjustments (to the ontology and guidance) for unfamiliar researchers. Following Steps 6-7, the published ontology included 230 classes, with six upper-level behavioural classes: human behaviour, individual human behaviour, individual human behaviour pattern, individual human behaviour change, population behaviour and population behaviour pattern. 'Individual human behaviour' was defined as " ", with its 159 subclasses organised across high-level classes relating to: experiences (e.g., playing); expression (e.g., laughing); reflectiveness; harm (e.g., self-injury behaviour); harm prevention; coping; domestic activities; goals; habits; health (e.g., undergoing vaccination); life-function (e.g., breathing behaviour); interactions with materials (e.g., consumption); bodily care (e.g., washing); position (e.g., postural behaviour); social environments (e.g., communication); and behavioural substitution. Additional classes needed for characterising behaviours (e.g., frequency and duration), their attributes and behavioural abstinence were included. Relations were defined for timings, locations, participants, mental processes, functions, goals and outcomes.
Conclusions: The HBO provides an extensive and detailed framework for describing human behaviours.
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http://dx.doi.org/10.12688/wellcomeopenres.21252.2 | DOI Listing |
Elife
September 2025
Human Biology and Primate Evolution, Institute of Biology, Freie Universität Berlin, Berlin, Germany.
Evidence indicates that transposable elements (TEs) can contribute to the evolution of new traits, with some TEs acting as deleterious elements while others are repurposed for beneficial roles in evolution. In mammals, some KRAB-ZNF proteins can serve as a key defense mechanism to repress TEs, offering genomic protection. Notably, the family of KRAB-ZNF genes evolves rapidly and exhibits diverse expression patterns in primate brains, where some TEs, including autonomous LINE-1 and non-autonomous Alu and SVA elements, remain mobile.
View Article and Find Full Text PDFJMIR Hum Factors
September 2025
Seidenberg School of Computer Science and Information Systems, Pace University, New York City, NY, United States.
Background: As information and communication technologies and artificial intelligence (AI) become deeply integrated into daily life, the focus on users' digital well-being has grown across academic and industrial fields. However, fragmented perspectives and approaches to digital well-being in AI-powered systems hinder a holistic understanding, leaving researchers and practitioners struggling to design truly human-centered AI systems.
Objective: This paper aims to address the fragmentation by synthesizing diverse perspectives and approaches to digital well-being through a systematic literature review.
Sci Prog
September 2025
Shenzhen University Sixth Affiliated Hospital, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Colorectal cancer ranks among the most prevalent and lethal malignant tumors globally. Historically, the incidence of colorectal cancer in China has been lower than that in developed European and American countries; however, recent trends indicate a rising incidence due to changes in dietary patterns and lifestyle. Lipids serve critical roles in human physiology, such as energy provision, cell membrane formation, signaling molecule function, and hormone synthesis.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Harvard Medical School, Boston, Massachusetts.
Importance: Research in behavioral economics has demonstrated that people have irrational biases, which make them susceptible to decisional shortcuts, or heuristics. The extent to which physicians consciously might use nudges to exploit these heuristics and thereby influence their patients' decision-making is unclear. In addition, ethical questions about the conscious use of nudges in medicine persist, yet little is known about how physicians experience and perceive their use.
View Article and Find Full Text PDF