An optimized DOI decoding method for a PET detector with nine-crystal-to-one-photodetector coupling.

Positron Emission Tomography (PET) benefits from depth-of-interaction (DOI) information to correct parallax errors introduced by thick scintillator crystals, especially in dedicated brain systems where edge-of-field DOI effects are most pronounced. Conventional light-sharing window (LSW) readout is limited to a four-to-one or two-to-one crystal-to-photodetector coupling and cannot decode DOI for central crystals under nine-to-one coupling schemes. This work proposes a novel detector architecture that overcomes these limitations, enabling DOI decoding for all crystals.We designed a LYSO scintillator array (1×1×20 mmcrystals in a12×15matrix) coupled to a4×5Hamamatsu MPPC array, incorporating transparent-interface LSWs. A nine-to-one coupling configuration was implemented, using collimation experiments and interpolation, a transfer function linking DOI to the MPPC signal ratio (ROM) was constructed. The detector performance was evaluated using floodmaps and energy spectrum, and the DOI mean absolute error (MAE) was calculated at interaction depths of 4 mm, 8 mm, 12 mm, and 16 mm in collimation experiments.The detector achieved an energy resolution of 11.8%. DOI MAEs at 4, 8, 12, and 16 mm were 2.34, 2.71, 3.73, and 5.37 mm, respectively, yielding an average MAE of 3.54 mm. DOI decoding was successfully performed for all crystals, including those centrally coupled. Compared to conventional LSW-based configurations, the detector achieved more than a 1.5-fold improvement in spatial resolution.The transparent-interface LSW design enables consistent DOI decoding across all scintillator elements at elevated coupling ratios. Moreover, by reducing pixel dimensions and enabling full-array DOI extraction, this architecture delivers superior positioning accuracy and spatial resolution, making it ideally suited for small animal PET and dedicated brain PET.