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Aims: This study investigated the prevalence and concordance of cardiometabolic risk markers among couples after a gestational diabetes mellitus (GDM)-affected pregnancy. It also examined whether selected demographic, socioeconomic and health behavioural factors could explain within-couple associations.
Materials And Methods: A cross-sectional study design was used. We included health examinations and questionnaire data from couples assessed 12 weeks after a pregnancy affected by GDM. We determined the prevalence and concordance of cardiometabolic risk markers (overweight or obesity, high waist circumference, metabolic syndrome, impaired fasting glucose [≥6.1 mmol/L], and stage 1 hypertension or more [≥130 mmHg/≥80 mmHg], along with health behaviour [dietary quality and physical activity]).
Results: A total of 196 couples were included. Overweight or obesity was present in 63.3% of women and 71.9% of partners, with concordance observed in 50.5% of couples. By comparison, 78.6% of women and 55.1% of partners had high waist circumferences, which was concordant in 48.5% of couples. Metabolic syndrome was identified in 9.2% of women and 24.0% of partners, suggesting a higher occurrence among partners with concordance in 5.1% of couples. Impaired fasting glucose was observed in 7.7% of women and 9.2% of partners, with concordance in 1.5% of couples. Stage 1 hypertension or more was observed in 31.1% of the women, 55.6% of the partners and concordant in 8.2% of couples. Cardiometabolic risk markers were associated within couples.
Conclusions: Detecting GDM in women may serve as an opportunity to identify partners at risk, underscoring the potential of couple-based or family-focused interventions.
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http://dx.doi.org/10.1111/dom.70017 | DOI Listing |
J Proteome Res
September 2025
Department of Neurology, West China Hospital, Sichuan University, Chengdu 610207, China.
Myasthenia gravis (MG) presents significant health and economic challenges. To identify novel biomarkers, we analyzed proteomic data from 52,704 UK Biobank individuals, focusing on 1463 baseline proteins with follow-up >10 years. Baseline and potential MG cases were 1:5 matched to controls by using propensity score matching.
View Article and Find Full Text PDFDiabetes Obes Metab
September 2025
Epidemiology, IQVIA, Frankfurt, Germany.
Aims: To examine the association between elevated body mass index (BMI) and a wide range of vascular and cardiometabolic diseases in men and women.
Materials And Methods: This retrospective cohort study used data from the IQVIA Disease Analyzer database, comprising anonymized records from over 3000 office-based physicians in Germany. We included 233 730 patients aged ≥40 years with at least one recorded BMI measurement between January 2005 and December 2023.
Neuropsychiatr Dis Treat
August 2025
Department of Psychiatry and Behavioral Sciences, New York Medical College, Valhalla, New York, USA.
Brexpiprazole is a second-generation antipsychotic with multiple indications, including the treatment of schizophrenia. As a partial dopamine agonist, brexpiprazole differs from most other antipsychotics, yet uncertainties about its full mechanism of action have led to some ambiguity among prescribers. To address this gap, an international panel of psychiatric experts was organized and convened with funding from Otsuka Pharmaceutical Europe Ltd and H.
View Article and Find Full Text PDFBackground And Aims: The role of anti-Müllerian hormone (AMH), a potential marker of the hypothalamic-pituitary-ovarian axis, is not well established in adolescent females. Typical epidemiologic studies use secondary sexual characteristics or chronological age as predictors for AMH. Skeletal maturity, an indicator of bone development, however, has not been examined in association with AMH in adolescent females.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
Department of Medical Sciences, University of Turin, Turin, Italy.
Context: Cardiometabolic complications are increasingly recognized in congenital adrenal hyperplasia (CAH) due to 21β-hydroxylase deficiency, but adult data remain limited.
Objective: To evaluate cardiovascular and metabolic alterations in adult patients with classic CAH under glucocorticoid treatment, compared to matched controls.
Methods: A cross-sectional study was conducted on adults with classic CAH and sex- and BMI-matched controls.