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Integrating heterogeneous healthcare datasets, such as claims and electronic health records, is important for making real-world data analytical-ready but poses challenges due to variations in data structures and clinical terminologies. We developed a systematic Extract, Transform, Load (ETL) pipeline to transform Medicare claims data into the Observational Medical Outcomes Partnership Common Data Model, enabling interoperability and standardized analytics. The ETL process was developed using the ETL-CMS framework and enhanced with updated procedures utilizing open-source ETL tools-WhiteRabbit. Rigorous testing ensured data accuracy and consistency, achieving a 99.2% passing rate in quality check assessment using the Data Quality Dashboard. Comparative analysis demonstrated an accurate representation of demographics and clinical comorbidities, with slight variations attributed to syntactic errors in the source data. This scalable framework fosters interoperability, supports global standards, and enables collaborative clinical research, advancing the integration of diverse healthcare datasets for improved analytics.
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http://dx.doi.org/10.3233/SHTI251106 | DOI Listing |
Clin J Am Soc Nephrol
September 2025
University College London Great Ormond Street Hospital for Children and Institute of Child Health, London, UK.
Background: Experience with icodextrin use in children on long-term peritoneal dialysis is limited. We describe international icodextrin prescription practices and their impact on clinical outcomes: ultrafiltration, blood pressure control, residual kidney function (RKF), technique and patient survival.
Methods: We included patients under 21 years enrolled in the International Pediatric Peritoneal Dialysis Network (IPPN) between 2007 and 2024, on automated PD with a daytime dwell.
Kidney360
September 2025
Department of Pediatrics, Division of Pediatric Nephrology, Baylor College of Medicine, Houston, TX, United States.
Background: Dialysis in neonates with ESKD is often associated with multiple comorbidities and the need for more intensified dialysis regimens. With recent advances in prenatal interventions and infant specific KRT, survival of neonates with ESKD has improved over the last decade. Little is known however about the impact on the health care system of improved survival in this population.
View Article and Find Full Text PDFJ Clin Invest
September 2025
The University of Texas at Austin, Austin, United States of America.
Background: Following SARS-CoV-2 infection, ~10-35% of COVID-19 patients experience long COVID (LC), in which debilitating symptoms persist for at least three months. Elucidating biologic underpinnings of LC could identify therapeutic opportunities.
Methods: We utilized machine learning methods on biologic analytes provided over 12-months after hospital discharge from >500 COVID-19 patients in the IMPACC cohort to identify a multi-omics "recovery factor", trained on patient-reported physical function survey scores.
J Med Internet Res
September 2025
Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany.
Background: The loss of a loved one is a common yet stressful event in later life. Internet- and mobile-based interventions have been proposed as an effective treatment approach for individuals with prolonged grief.
Objective: The AgE-health study aimed to investigate the efficacy of an eHealth intervention, trauer@ktiv, in reducing prolonged grief symptoms in a sample of older adults.
Cereb Cortex
August 2025
Brain and Cognition, KU Leuven, Tiensestraat 102, 3000 Leuven, Belgium.
Centro-parietal electroencephalogram signals (centro-parietal positivity and error positivity) correlate with the reported level of confidence. According to recent computational work these signals reflect evidence which feeds into the computation of confidence, not directly confidence. To test this prediction, we causally manipulated prior beliefs to selectively affect confidence, while leaving objective task performance unaffected.
View Article and Find Full Text PDF