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BackgroundThis study aims to investigate the validity of the Charlson Comorbidity Index (CCI) and Elixhauser Comorbidity Index (ECI) as predictive tools for adverse outcomes following total ankle arthroplasty (TAA).MethodsThe Nationwide Readmissions Database (NRD) was queried from 2015 to 2020 to identify 29 705 patients undergoing primary TAA. Patients' comorbidity was measured via CCI and ECI scores, and patients who experienced adverse postoperative outcomes (any complication, readmission, mortality, extended length of stay (LOS), and adverse discharge) were identified.ResultsBoth the ECI and CCI comorbidity indices predicted mortality with excellent accuracy (Area under the Curve [AUC] = 0.88 for both). However, ECI outperformed CCI in predicting complications, extended LOS, and adverse discharge, although both had poor predictive capability for these outcomes.ConclusionThese findings indicate that while ECI and CCI are capable of predicting postoperative mortality following TAA, there is a need for alternative models that better predict other postoperative adverse outcomes.Level of Evidence:Level III; Retrospective cohort study.
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http://dx.doi.org/10.1177/19386400251355652 | DOI Listing |
JCI Insight
September 2025
Edinburgh Medical School: Biomedical Sciences & Euan MacDonald Centre for M, University of Edinburgh, Edinburgh, United Kingdom.
Spinal muscular atrophy (SMA) is a neuromuscular disease caused by low levels of SMN protein. Several therapeutic approaches boosting SMN are approved for human patients, delivering remarkable improvements in lifespan and symptoms. However, emerging phenotypes, including neurodevelopmental comorbidities, are being reported in some treated SMA patients, indicative of alterations in brain development.
View Article and Find Full Text PDFG Ital Nefrol
August 2025
Infermiere Professionale SSD Nefrologia e Dialisi P.O. Soverato, ASP CZ.
Management of diabetes mellitus in hemodialysis is highly complex due to increased glycemic variability and hypoglycemic risk. The use of technologies applied to diabetes has been shown to improve glycemic control, however data in dialysis patients are limited. To describe the efficacy and safety of the minimed 780G AHCL system in a stable hemodialysis patient and during hospitalization in the Intensive Care Unit (ICU).
View Article and Find Full Text PDFJ Korean Med Sci
September 2025
Department of Preventive Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Background: Clinics and hospitals in South Korea are often perceived as competitors to each other. This study examines the overlapping roles in providing primary care provision between clinics and hospitals by analyzing the healthcare facility type where patients first receive diagnoses of hypertension (HTN) or diabetes mellitus (DM). We also explore the characteristics of patients that influence their choice of healthcare facility and compare healthcare utilization patterns in the first year post-diagnosis by facility type.
View Article and Find Full Text PDFBrain Behav
September 2025
Tongde Hospital of Zhejiang Province Affiliated to Zhejiang Chinese Medical University(Tongde Hospital of Zhejiang Province), Hangzhou, China.
Background: Mental disorders frequently co-occur with pain, yet pain mechanisms in non-peripheral etiologies (e.g., chronic psychological stress) remain underexplored.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Health Statistics, School of Public Health, Shandong Second Medical University, Weifang, Shandong, China.
Both psoriasis and autoimmune thyroid diseases are characterized by chronic inflammation. The previous studies indicated a potential association between psoriasis and autoimmune thyroid diseases. However, the direction and nature of these relationships remain unclear.
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