Failure Rate of Fixed Versus Mobile Bearing Total Ankle Arthroplasty.

Background: With an increasing number of total ankle arthroplasties (TAAs) being performed and an abundance of new survivorship data available, an updated literature review is needed to better understand the impact of different types of implants on outcomes of TAA. This study aims to review existing literature and identify trends among current individual fixed versus mobile bearing TAA implants.

Methods: A comprehensive search of PubMed, CINAHL, and Scopus for all articles published between 2004 and 2024 examining outcomes of third- and fourth-generation TAAs was conducted with a minimum 2-year mean follow-up.

Assessing the Predictive Accuracy of Popular Comorbidity Indices in Total Ankle Arthroplasty Outcomes.

BackgroundThis study aims to investigate the validity of the Charlson Comorbidity Index (CCI) and Elixhauser Comorbidity Index (ECI) as predictive tools for adverse outcomes following total ankle arthroplasty (TAA).MethodsThe Nationwide Readmissions Database (NRD) was queried from 2015 to 2020 to identify 29 705 patients undergoing primary TAA. Patients' comorbidity was measured via CCI and ECI scores, and patients who experienced adverse postoperative outcomes (any complication, readmission, mortality, extended length of stay (LOS), and adverse discharge) were identified.

One-pot synthesis of primary phosphines from white phosphorus.

Aryl and alkyl chlorides are inexpensive and readily accessible, making them ideal reagents for converting white phosphorus (P) into primary phosphines RPH. However, methods for achieving this transformation directly, bypassing undesired intermediates like PCl, have remained elusive. This report describes the 'one-pot' synthesis of primary organophosphines from P using organotin compounds, including a multi-gram synthesis of PhPH featuring efficient recovery of organotin reagents for potential recycling.

The Success of Corticosteroid Injections in Treating Midfoot and Transverse Tarsal Joint.

Unlabelled: BackgroundThis study aims to quantify how well midfoot and transverse tarsal joint arthritis can be treated nonoperatively with fluoroscopic-guided injections.

Methods: We reviewed the records of 132 patients (155 feet) diagnosed with midfoot arthritis between 2015 and 2019, who received conservative management via periodic fluoroscopic-guided steroid injections. Patients were told to follow-up as needed after the injection.

Consumer Preferences for Total Ankle Arthroplasty Versus Ankle Arthrodesis: A Conjoint Analysis of 1,410 US Healthcare Consumers.

Introduction: Few studies have analyzed consumer preferences for total ankle arthroplasty (TAA) versus ankle arthrodesis (AA). The purpose of this study was to understand consumer preferences for TAA and AA based on cost, outcomes, and other treatment attributes.

Methods: A conjoint analysis was developed and distributed using Amazon Mechanical Turk to US healthcare consumers.

The effect of preoperative osteoporosis on postoperative outcomes following total ankle arthroplasty.

Introduction: Recent literature, particularly in the fields of total joint arthroplasty, has raised concern for increased perioperative complications following joint arthroplasty in patients with osteoporosis. The purpose of this study is to evaluate the influence of preoperative osteoporosis on 6-month postoperative outcomes following total ankle arthroplasty (TAA).

Methods: The Nationwide Readmissions Database (NRD) was queried from 2015 to 2020 to identify 29,705 patients undergoing primary elective TAA.

Preoperative Alcohol Use Disorder Is Associated With Increased Morbidity and Costs in Ankle Arthrodesis.

IntroductionThe purpose of this study is to evaluate the influence of alcohol use disorder (AUD) on postoperative outcomes following ankle anrthrodesis (AA).MethodsThis investigation utilized the Nationwide Readmissions Database from 2016 to 2020, identifying 26 705 patients who underwent primary elective AA, and further stratifying based on the presence of preoperative AUD (N = 612, 2.29%).

Counterintuitive Photochemistry of an Isolated Acridinyl Radical: ConPET via Preassembly, Solvated Electrons or a Long-Lived Excited State?

Photoredox chemistry has seen a dramatic rise in popularity in recent years, but mechanistic understanding has persistently lagged behind reaction development itself. This is particularly true for the emerging area of consecutive photoinduced electron transfer (conPET), which has attracted both great interest due to its ability to activate inert substrates selectively and under mild conditions and continuing controversy over its mechanistic feasibility. We describe herein the isolation of the key radical intermediate state of an acridinium-based conPET catalyst and detailed investigations of its photochemistry by a suite of (photo)reactivity, photoluminescence and transient absorption techniques, supported by computational studies.

Assessing the costs of midfoot arthrodesis: A retrospective cohort study.

This retrospective cohort study aims to determine the economic cost of midfoot arthrodesis when treating midfoot arthritis, identifying the major driving forces of cost. A retrospective analysis was conducted on midfoot arthrodesis cases in South Carolina from 2012 to 2020 using the South Carolina Revenue and Fiscal Affairs (SCRFA) database. Patient cases were identified by ICD-9, ICD-10, or CPT code, yielding a total of 1,313 cases included in our analysis.

Effect of Preoperative Dehydration on Postoperative Complications Following Ankle Fracture Open Reduction Internal Fixation.

IntroductionThis study aims to analyze the effect of preoperative fluid status on 30-day complication, readmission, reoperation, and mortality rates following ankle fracture procedures.MethodsThe American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) database was queried to identify 27 175 patients undergoing open reduction and internal fixation (ORIF)of ankle fracture. Patients were stratified by hydration status (normal = 18 761, dehydrated = 8414) with preoperative dehydration, defined as a blood urea nitrogen (BUN)-to-creatinine (Cr) ratio (BUN/Cr) greater than 20.

Preoperative opioid dependence associated with increased costs and wound dehiscence following total ankle arthroplasty.

Introduction: The purpose of this study is to evaluate the influence of chronic opioid dependence on postoperative outcomes following primary total ankle arthroplasty (TAA).

Methods: The Nationwide Readmissions Database (NRD) was queried from 2016 to 2020 to identify 29,751 patients undergoing primary elective TAA with patients divided into cohorts based on the presence of preoperative opioid dependence (861 patients; 2.9 %).

Diversity in Medical School, Orthopaedic Surgery Residency, and ACGME-Accredited Foot and Ankle Orthopaedic Surgery Fellowship Training by Gender, Race, and Ethnicity.

Introduction: Increasing diversity in the US health care workforce is a topic of increasing scrutiny and interest. This study analyzes the pipeline of demographic diversity for Accreditation Council for Graduate Medical Education (ACGME)-accredited foot and ankle orthopaedic surgery fellowship training.

Methods: This was a cross-sectional study of medical students, orthopaedic surgery residents, and orthopaedic foot and ankle fellows at US-accredited training programs from 2013 to 2022.

Design Rational for Total Ankle Arthroplasty: An Update.

The design of total ankle arthroplasty (TAA) systems is rapidly evolving as device companies try to keep pace with the expansion of surgical indications and a refinement of techniques for TAA. Even since the publication of the latest "update," published in 2018, three new designs and three updates on preexisting third-generation implants came onto the market. Improvements in third-generation TAA systems include minimal bone resection, retaining ligamentous support, and anatomic balancing.

Re-evaluation of Cyclic Peptide Binding to Neurotensin Receptor 1 by Shifting the Peptide Register during Synthesis.

The head-to-tail cyclic peptide [Arg-Lys-Pro-Tyr-Tle-Leu] (peptide , where Tle is l--Leu) has previously been reported to bind to neurotensin receptor 1 (NTS1) (pKi = 5.97). Upon seeking to reproduce this finding, we found that peptide did not have a measurable affinity for NTS1.

Understanding ACGME Standards for Simulation: A Document Analysis of Institutional and Program Requirements.

Our institution has established priorities for graduate medical education (GME) simulation which include increasing adoption of, garnering additional financial support for, and creating a core simulation curriculum. Better understanding of the Accreditation Council for Graduate Medical Education (ACGME) simulation requirements will inform our efforts and serve as a guide for other institutions. The purpose of this study was to perform a structured review of ACGME simulation standards using a document analysis to guide GME simulation activities at an institutional level.

Lower Total Shoulder Arthroplasty Cost of Care at an Ambulatory Surgical Center Versus a Main Hospital.

Introduction: Total shoulder arthroplasty (TSA) is an increasingly common orthopaedic procedure. Expansion of TSA to outpatient surgical settings has the potential to reduce costs, although there is limited research on the cost and efficiency of this shift in surgical site of care. The purpose of this study is to compare costs and efficiency of TSA between an ambulatory surgical center (ASC) and a hospital.

A systematic review of outcomes of total ankle arthroplasty with INBONE II.

Background: This study systematically reviews the literature and reports on outcomes of total ankle arthroplasty (TAA) with the INBONE II fixed-bearing implant.

Methods: PubMed, SCOPUS and CINAHL were searched for clinical studies reporting INBONE II specific outcomes from database inception through July 13th, 2024, according to the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) guidelines.

Results: Seven primary TAA studies and 4 revision TAA studies were included with 406 and 114 patients respectively.

Closing the Loop: Low-Waste Phosphorus Functionalization Enabled by Simple Disulfides.

Useful monophosphorus products are obtained from both white and red phosphorus via a simple strategy involving initial oxidation by aryl disulfides followed by quenching with nucleophiles. Direct transformations of elemental phosphorus are usually very challenging, forcing chemists to instead rely on inefficient and hazardous multi-step methods. However, here they are achieved using inexpensive and easy-to-handle reagents, providing access to diverse P-C, P-N and P-O bonded products in good yields.

Dynamic interface printing.

Additive manufacturing is an expanding multidisciplinary field encompassing applications including medical devices, aerospace components, microfabrication strategies and artificial organs. Among additive manufacturing approaches, light-based printing technologies, including two-photon polymerization, projection micro stereolithography and volumetric printing, have garnered significant attention due to their speed, resolution or potential applications for biofabrication. Here we introduce dynamic interface printing, a new 3D printing approach that leverages an acoustically modulated, constrained air-liquid boundary to rapidly generate centimetre-scale 3D structures within tens of seconds.

Learning Curve of a Robotic Bio-Tissue Intestinal Anastomosis: Implications for Surgical Training Curricula.

Objective: The integration of robotic surgical training in a time-scarce residency program is a challenge for surgical educators. Simulation-based training is a tool that allows residents to acquire the necessary robotic skills without compromising patient safety. This study aimed to assess the learning curve of a robotic inanimate intestinal anastomosis drill.

From the simulation lab to the operating room: simulation performance predicts intraoperative performance in robotic gastrojejunostomy.

Background: Simulation and video-based assessment (VBA) offer residents the opportunity to develop operative skills while ensuring patient safety. This study aims to determine whether simulation training can predict residents' operative performance, focusing on the gastrojejunal (GJ) anastomosis during robotic pancreatoduodenectomy.

Methods: Twenty-seven general surgery residents completed simulated robotic GJ drills and subsequently performed GJs in the operating room (OR).

Using OR Black Box Technology to Determine Quality Improvement Outcomes for In-situ Timeout and Debrief Simulation.

Objective: The purpose of this study was to determine quality improvement outcomes following the pilot implementation of an in-situ simulation designed to enhance surgical safety checklist performance.

Background: OR Black Box (ORBB) technology allows near real-time assessment for surgical safety checklist performance. Before our study, timeout quality was 73.

Unravelling White Phosphorus: Experimental and Computational Studies Reveal the Mechanisms of P Hydrostannylation.

The hydrostannylation of white phosphorus (P) allows this crucial industrial precursor to be easily transformed into useful P products via direct, 'one pot' (or even catalytic) procedures. However, a thorough mechanistic understanding of this transformation has remained elusive, hindering attempts to use this rare example of successful, direct P functionalization as a model for further reaction development. Here, we provide a deep and generalizable mechanistic picture for P hydrostannylation by combining DFT calculations with in situ P NMR reaction monitoring and kinetic trapping of previously unobservable reaction intermediates using bulky tin hydrides.