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http://dx.doi.org/10.1200/PO-25-00434 | DOI Listing |
BMC Med
September 2025
Center for Clinical Epidemiology and Methodology (CCEM), The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong, 510317, China.
Background: The International Committee of Medical Journal Editors (ICMJE) recommends that trial authors must specify data sharing plans when trials are registered and published, yet this uptake remains unclear. We aimed to assess the practice of data sharing plans in trial registration platforms and the concordance between registered and published data sharing plans.
Methods: We included clinical trials published between 2021 and 2023 in six high-profile journals (The Lancet, The New England Journal of Medicine, JAMA, BMJ, JAMA Internal Medicine, and Annals of Internal Medicine) that enrolled participants no earlier than 2019 and registered on clinical trial platforms.
IJID Reg
September 2025
College of Medicine and Health Sciences, Sultan Qaboos University, Seeb, Oman.
Objectives: Rising antimicrobial resistance (AMR) in urinary tract infections (UTI) poses a global challenge. Evidence-based treatment of cystitis requires local resistance data. The DASH to Protect Antibiotics (https://dashuti.
View Article and Find Full Text PDFJCO Precis Oncol
August 2025
Department of Urology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Genes (Basel)
July 2025
State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
: Tumor-associated macrophages (TAMs) are critical regulators of the hepatocellular carcinoma (HCC) microenvironment, yet their epigenetic heterogeneity and regulatory programs remain poorly defined. : We performed integrative analysis on single-cell RNA-seq and ATAC-seq profiling of HCC patients to dissect TAM subtypes at high resolution. By correlating chromatin accessibility with gene expression, we identified cell-type-specific candidate -regulatory elements (CREs).
View Article and Find Full Text PDFIn Brief: By tissue-selective next-generation sequencing, we showed that adenomyotic epithelium harbored genomic alterations thought to be relevant to the development and progression of adenomyosis, including somatic mutations in several cancer-associated genes with high mutant allele frequencies and the gain of chromosome 1q. Clonal relationships among multiple adenomyotic lesions and the normal uterine endometrium delineate the oligoclonal origin of adenomyosis and the spatial expansion of mutant clones.
Abstract: To identify the distinctive features of mutation profiles in adenomyosis compared to the coexisting normal endometrium, multi-regional sampling was performed to collect samples of adenomyotic epithelium (n = 41), adenomyotic stroma (n = 12), and uterine endometrial epithelium (n = 53) from 21 patients with adenomyosis.