Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: This paper aims to reveal the impact of HOXC6 on oral cancer development through the regulation of BCAT1 and the molecular mechanism.
Methods: BCAT1 expression in oral cancer tissues and adjacent tissues was verified by western blot analysis and RT-qPCR. After knocking down BCAT1, the HN6 and HN30 cell proliferation, migration, invasion, and apoptosis were detected. The upstream mechanism of BCAT1 elevation was investigated by bioinformatics analysis. HOXC6 expression was detected by immunohistochemistry in oral cancer and adjacent tissues. ChIP and dual-luciferase assay were used to detect the interaction between HOXC6 and the BCAT1 promoter. Rescue experiments were carried out to substantiate the malignant phenotype and epithelial-to-mesenchymal transition (EMT) of oral cancer cells. An in vivo xenograft tumor model was constructed.
Results: BCAT1 and HOXC6 were abnormally high in oral cancer tissues. Inhibition of BCAT1 suppressed the proliferation, migration, invasion, and EMT, and promoted apoptosis of oral cancer cells. HOXC6 downregulation curbed the malignant behavior and EMT program of oral cancer cells. HOXC6 was enriched in the BCAT1 promoter in oral cancer cells. HOXC6 silencing downregulated BCAT1 expression. Transcriptional activation of BCAT1 by HOXC6 promoted oral cancer progression.
Conclusion: HOXC6 knockdown inhibits BCAT1 expression to suppress oral cancer development.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/odi.70049 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of osteotomy angle on bone failure risk in a modified pull-through approach: a finite element analysis.
BMC Oral Health
September 2025
Department of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Background: A modified pull-through approach represents a promising treatment strategy to access tumors in the posterior oral cavity. The design of the wedge osteotomy plays a key role in preserving postoperative mechanical stability while enabling surgical access. However, the optimal osteotomy design to reduce fracture risk remains unclear.
View Article and Find Full Text PDFEnhancing submandibular gland resection: A retrospective study on the efficacy of the ORBEYE 3D exoscope.
Oral Maxillofac Surg
September 2025
Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Shinmachi 2-5-1, Hirakata-city, Osaka, Japan.
Purpose: For submandibular gland resection, conventional surgery with the naked eye remains the standard. With its excellent automatic focus and high magnification, the ORBEYE 3D exoscope enables precise submandibular gland resection with less stress. Therefore, we aimed to examine the usefulness of the exoscope in submandibular gland resection.
View Article and Find Full Text PDFThe X-Age Project to construct a Chinese aging clock.
Nat Aging
September 2025
Aging Biomarker Consortium (ABC), Beijing, China.
The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age-related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual's physiological and molecular state, across diverse Chinese cohorts.
View Article and Find Full Text PDFNEK9-mediated Wnt signalling repressor TLE3 rewires Docetaxel resistance in cancer cells by inducing pyroptosis.
Br J Cancer
September 2025
Institute of Life Sciences, Bhubaneswar, Odisha, India.
Background: Docetaxel is the most common chemotherapy regimen for several neoplasms, including advanced OSCC (Oral Squamous Cell Carcinoma). Unfortunately, chemoresistance leads to relapse and adverse disease outcomes.
Methods: We performed CRISPR-based kinome screening to identify potential players of Docetaxel resistance.
Comment on "Low skeletal muscle mass and not systemic inflammation is associated with complications after free forearm flap reconstruction in oral cancer patients".
Oral Oncol
September 2025
Department of Community Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 602105, India. Electronic address: