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The aim of this paper is two-fold: to investigate development of a Construct Specification Equation (CSE) for UL task difficulty, , and a CSE for person UL ability, , in support of the validity of these two constructs. Measurements of UL task difficulty, , and person UL ability, were derived from applying the Rasch model on the Tetraplegia Upper Limb Activity Questionnaire (TUAQ). The formulations of CSEs as explanations of the two constructs were done using Principal Component Regression (PCR). The CSE for UL task difficulty, , was to a large degree explained by the number of joints involved and the CSE for person UL ability, , was dominated by grasp-related variables. Pearson coefficients of 0.94 and 0.73 were obtained between UL task difficulty and UL person ability from the CSE, respectively, when correlated with each empirical measure. The present work has both explored and extended the methodology for using more qualitative explanatory variables. Specifically, for UL measurements for people with tetraplegia a good CSE for task difficulty, , supports the validity of TUAQ when measuring person UL ability. Additionally, the CSE formulated for person ability, , can be used both for validation purposes as well as a clinical tool.
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http://dx.doi.org/10.1038/s41598-025-98626-4 | DOI Listing |
Stem Cell Res
September 2025
Department of General Pediatrics, Neonatology, and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf 40225, Germany. Electronic address:
Pathogenic variants in the gene COQ4 cause primary coenzyme Q deficiency, which is associated with symptoms ranging from early epileptic encephalopathy up to adult-onset ataxia-spasticity spectrum disease. We genetically modified commercially available wild-type iPS cells by using a CRISPR/Cas9 approach to create heterozygous and homozygous isogenic cell lines carrying the disease-causing COQ4 variants c.458C > T, p.
View Article and Find Full Text PDFJACC Heart Fail
September 2025
Université de Lorraine, Inserm, Centre d'Investigations Cliniques Plurithématique 1433, Centre Hospitalier Régional Universitaire de Nancy, Nancy, France.
JMIR Med Inform
September 2025
Departments of Radiology, The Third Affiliated Hospital, Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, Guangdong, 510630, China, 86 18922109279, 86 20852523108.
Background: Despite the Coronary Artery Reporting and Data System (CAD-RADS) providing a standardized approach, radiologists continue to favor free-text reports. This preference creates significant challenges for data extraction and analysis in longitudinal studies, potentially limiting large-scale research and quality assessment initiatives.
Objective: To evaluate the ability of the generative pre-trained transformer (GPT)-4o model to convert real-world coronary computed tomography angiography (CCTA) free-text reports into structured data and automatically identify CAD-RADS categories and P categories.
Pol Merkur Lekarski
September 2025
VOLODYMYR DAHL EAST UKRAINIAN NATIONAL UNIVERSITY, KYIV, UKRAINE.
Objective: Aim: The aim is to conduct medical and sociological research on public awareness of the impact of rational nutrition on promoting human health and preventing chronic non-communicable diseases.
Patients And Methods: Materials and Methods: The research was conducted in 2022-2024 and involved 214 respondents of different ages and genders who were patients of outpatient clinics in Zhytomyr (Ukraine). Research methods included theoretical analysis of literary sources, medical and sociological (questionnaire), mathematical and statistical, system analysis, and logical generalization.
J Bras Pneumol
September 2025
. Departamento de Pneumologia do Hospital Infante D. Pedro, Unidade Local de Saúde da Região de Aveiro, Aveiro, Portugal.
Objectives: This study explores the relationship between inhaler visual identification, naming, and adherence outcomes, and evaluates the potential of combining these factors into a screening tool for identifying poor adherence.
Methods: This observational, prospective study included adult patients with COPD, asthma, or asthma+COPD who had been on chronic inhalation therapy for at least the past year. Data were collected through patient interviews and medical records.