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While structured treatment programs for children and adolescents with psychiatric disorders exist, their geographic distribution remains unclear. Specialized addiction treatment facilities for young patients are particularly scarce in Germany. This study examines access to child and adolescent psychiatric care using a driving time-based isochrone analysis to identify regional disparities. We mapped outpatient clinics, inpatient departments, day clinics as well as specialized addiction centers and calculated the isochrones for 30, 60, 90, and 120 minutes of driving time. We then aggregated the resulting geometric areas and applied them to the Global Human Settlement Population Grid 2025 to estimate the number of German inhabitants with access to these centers within the specified time frames. While 98 % of Germans can reach a psychiatric care unit within 1 hour, the coverage is lower for specialized addiction clinics (60.5%). Within 120 minutes, more than 95 % of Germans can reach a center of any network. In addition to the generally underserved rural areas, such as those in northeastern Germany, specialized addiction clinics are underrepresented across all regions. Germany's adolescent psychiatric care is relatively strong, though some regions still face limited access and pose challenges to patients, especially regarding acute crisis interventions, where long travel times delay urgent care.
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http://dx.doi.org/10.1024/1422-4917/a001037 | DOI Listing |
Alzheimers Dement
September 2025
Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Introduction: Mild cognitive impairment (MCI) represents a transitional stage between normal aging and dementia. We investigate associations among cardiovascular and metabolic disorders (hypertension, diabetes mellitus, and hyperlipidemia) and diagnosis (normal; amnestic [aMCI]; and non-amnestic [naMCI]).
Methods: Multinomial logistic regressions of participant data (N = 8737; age = 70.
Mol Psychiatry
September 2025
Department of Pharmacology, School of Basic Medicine and Department of Pharmacy, Tongji Hospital, Tongji Medical College; and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. chenjg@hu
Dysfunction of parvalbumin-expressing interneurons (PV-INs) in the cerebral cortex has been implicated in major depressive disorder. Perineuronal nets (PNNs), which encapsulate PV-INs, are considered to influence the structural and functional properties of PV-INs. Semaphorin 3A (Sema3A) is a secreted protein constituent of PNNs, but the specific roles of Sema3A in modulating PV-INs during stress remain unknown.
View Article and Find Full Text PDFMol Psychiatry
September 2025
Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
Stimulant Use Disorder (StUD) is a pervasive and extremely dangerous form of addiction for which there are currently no approved medications. Discovering treatments will require a deep understanding of the neural mechanisms underlying the behavioral effects of stimulant drugs. A major target is the mesocorticolimbic system.
View Article and Find Full Text PDFTransl Psychiatry
September 2025
Department of Human Sciences, The Ohio State University, Columbus, OH, USA.
A ketogenic diet (KD) has shown promise as an adjunctive therapy for neurological and neuropsychiatric disorders, including bipolar disorder and major depressive disorder (MDD). We examined tolerance for a KD in young adults with MDD and assessed symptoms of depression and metabolic health. Students (n = 24) with a confirmed diagnosis of MDD at baseline receiving standard of care counseling and/or medication treatment were enrolled in a 10-12 week KD intervention that included partial provision of ketogenic-appropriate food items, frequent dietary counseling, and daily morning tracking of capillary R-beta-hydroxybutyrate (R-BHB).
View Article and Find Full Text PDF