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Individuals with pre-existing heavy alcohol use, prior traumatic exposures, and psychiatric disorders were considered an at-risk group for increased alcohol use and problems in the context of the COVID-19 pandemic. This study recruited from a multi-centre longitudinal cohort study of US military service members/veterans with combat exposure to examine the trajectories of alcohol use and problems in the context of a prolonged stressor. Individuals who endorsed heavy drinking and completed a measure of PTSD symptoms prior to the pandemic were invited to participate in a longitudinal survey study at three time points, three months apart, during the second year of the pandemic. Participants ( = 44) completed surveys assessing alcohol consumption and alcohol-related problems (via the AUDIT), PTSD symptoms (via the PCL-5), and infection mitigation behaviours (via a COVID-19 specific survey). Random intercept models were fitted to the longitudinal data for each of these outcomes, covarying for demographics, pandemic quarantine/physical distancing experience, pre-pandemic baseline alcohol consumption and PTSD symptoms, and time-varying alcohol consumption and alcohol-related problems as well as PTSD symptoms. We did not find an increase in alcohol consumption or problems over time. However, pre-pandemic alcohol consumption predicted alcohol consumption over time ( = 0.52, SE = 0.11, < .01). Time-varying alcohol consumption and PTSD symptoms predicted alcohol problems over time ( = 0.84, SE = 0.18, < .01; = 0.04, SE = 0.02, < .05, respectively). Findings highlight the relevance of pre-existing hazardous alcohol consumption prior to stressors as well as ongoing consumption and PTSD symptoms as risk factors for alcohol-related problems. Findings captured more chronic impacts of pandemic stressors and demonstrated that heavy drinking and PTSD are notable risk factors for alcohol-related problems even if in the context of stabilizing, albeit still high, alcohol use.
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http://dx.doi.org/10.1080/20008066.2025.2534310 | DOI Listing |
Front Neurosci
August 2025
Department of Health Sciences, Universidade Estadual de Santa Cruz, Ilhéus, Brazil.
Introduction: Studies suggest that serotonin (5-HT) plays an important role in alcohol use disorder (AUD). While several receptor subtypes modulate the role of 5-HT in AUD, evidence suggests that 5-HT and 5-HT receptors may be directly involved in alcohol drinking due to their interaction with the mesolimbic dopaminergic system. The aim of the present study was to investigate the effects of 5-HT and 5-HT antagonists, alone or in combination, on the acquisition and expression (i.
View Article and Find Full Text PDFInfect Prev Pract
December 2025
Department of Hospital Hygiene and Epidemiology, University Hospital Trnava, Trnava, Slovakia.
Background: Hand hygiene (HH) among healthcare professionals (HCPs) is a key component in ensuring safe and high-quality healthcare. Monitoring the Five moments for HH according to World Health Organization (WHO) guidelines remains the gold standard for compliance assessment. Proper HH is the most effective measure to prevent healthcare-associated infections (HAI).
View Article and Find Full Text PDFFront Psychiatry
August 2025
Department of Neurosurgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Introduction: Anxiety, depression, and insomnia are common among older patients with tuberculosis (TB), yet their associations with inflammatory responses and drug-induced liver injury (DILI) remain insufficiently explored. This study aimed to identify distinct inflammation-DILI phenotypes in older TB patients and examine differences in anxiety, depression, and insomnia across subgroups.
Methods: In this cross-sectional study, 251 older TB patients were evaluated.
Leg Med (Tokyo)
September 2025
Department of Analytical Chemistry, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2-4-41, Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
This study investigated headspace solid-phase microextraction (HS-SPME)-gas chromatography (GS)/mass spectrometry as a low-complexity method for accurate measurement of blood alcohol concentration (BAC) changes in humans over time following alcohol consumption. The aim was to develop an analytical method that would require as small blood samples as possible-smaller than that required for the conventional method-thereby reducing the burden on the subject. Polyethylene glycol (PEG) was used as the fiber material for SPME, and a DB-WAX capillary column was used for GC.
View Article and Find Full Text PDFJ Trauma Stress
September 2025
Department of Psychology, Palo Alto University, Palo Alto, California, USA.
Sexual assault on college campuses remains a pervasive issue, with students who consume alcohol at heightened risk for more frequent and severe victimization. A history of childhood trauma and specific drinking motives may increase this vulnerability, yet little research has examined how these factors interact to inform the impact of sexual assault frequency and severity during college. In this study, we used Bayesian multiple regression and random forest modeling to analyze the impact of childhood trauma and drinking motives on sexual assault among college students (N = 624).
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