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A 53-year-old right-hand-dominant man presented with a recurrent, painful mass localized to the volar surface of the right small finger, leading to discomfort and impaired function. Radiographic imaging was unremarkable for osseous involvement. Surgical excision followed by histopathological and immunohistochemical (IHC) analysis established the diagnosis of angioleiomyoma, marked by desmin-positive smooth muscle fibers and CD34-positive vasculature. Given its infrequency in the hand and overlap with more common benign lesions, angioleiomyoma remains diagnostically elusive. This report emphasizes the pivotal role of tissue-based diagnostics and supports excision as a definitive treatment modality.
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http://dx.doi.org/10.7759/cureus.89165 | DOI Listing |
Brain Stimul
September 2025
Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. Electronic address:
Background: Precisely timed brain stimulation, such as phase-locked deep brain stimulation (PLDBS), offers a promising approach to modulating dysfunctional neural networks by enhancing or suppressing specific oscillations. However, its clinical application has been hindered by the lack of user-friendly systems and the challenge of real-time phase estimation amid stimulation artifacts.
Material And Method: In this work, we developed a clinically translatable PLDBS framework that enables real-time, cycle-by-cycle stimulation using standard amplifiers and a computer-in-the-loop system.
PLoS Pathog
September 2025
Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America.
Hepatitis C virus (HCV) exhibits a narrow species tropism, causing robust infections only in humans and experimentally inoculated chimpanzees. While many host factors and restriction factors are known, many more likely remain unknown, which has limited the development of mouse or other small animal models for HCV. One putative restriction factor, the black flying fox orthologue of receptor transporter protein 4 (RTP4), was previously shown to potently inhibit viral genome replication of several ER-replicating RNA viruses.
View Article and Find Full Text PDFSkeletal Radiol
September 2025
Department of Diagnostic Radiology, Cleveland Clinic, Cleveland, OH, USA.
Objective: To retrospectively evaluate outcomes of an ultrasound-guided A1 pulley fenestration release technique using small-gauge (hypodermic or spinal) needles for the treatment of trigger finger (TF).
Materials And Methods: A retrospective chart review of all TF fenestration release procedures performed by two musculoskeletal radiologists between July 2020 and August 2024 was conducted. The technique included a steroid injection after release.
ACS Nano
September 2025
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Nanoparticles bind to proteins in cells selectively and form a protein corona around them. However, the mechanisms of protein conformational changes underlying the interactions between nanoparticles and protein coronas remain poorly understood. In this study, we prepared small molecule self-assembled nanoparticles (Aloin NPs) as a research tool to investigate the allosteric mechanism of protein coronas.
View Article and Find Full Text PDFMol Cell
September 2025
Department of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA, USA. Electronic address:
In animal germ cells, PIWI proteins use piRNAs to detect active selfish genetic elements. Base-pairing to a piRNA defines transposon recognition, but how this interaction triggers a defensive response remains unclear. Here, we identify a transposon recognition complex composed of the silkworm proteins Siwi, GTSF1, and Maelstrom.
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