Cervical Paratracheal Bronchogenic Cyst Mimicking Nodal Metastatic Disease in a Colorectal Cancer Patient: Diagnostic Utility of Neck Ultrasound-Guided Fine Needle Aspiration.

Bronchogenic cysts are rare congenital lesions, typically identified in childhood but occasionally found in adults as incidental findings on imaging. In oncology patients, these lesions can present a diagnostic challenge due to their potential to mimic metastatic disease. We report a case of a 78-year-old woman undergoing routine surveillance for Stage II colorectal cancer who was found to have a paratracheal cystic lesion suspicious for malignancy.

Squamous Papilloma of the Esophagus in a Patient With Refractory Gastroesophageal Reflux Disease.

We report a case of a 35-year-old woman with persistent gastroesophageal reflux disease (GERD) despite lifestyle modification and medical therapy. Endoscopy revealed a squamous papilloma in the distal esophagus, a rare benign lesion linked to chronic mucosal irritation. The lesion was excised, and histopathology confirmed squamous papilloma without dysplasia.

Idiopathic Eosinophilic Cholecystitis in the Setting of Cholelithiasis: A Case Report and Brief Literature Review.

Eosinophilic cholecystitis (EC) is a rare inflammatory condition characterized by prominent eosinophilic infiltration of the gallbladder wall. It often mimics typical acute cholecystitis and is usually diagnosed only after histopathological examination. This case report discusses a 69-year-old woman presenting with symptoms of acute cholecystitis who was later found to have EC.

Angioleiomyoma of the Volar Aspect of the Right Small Finger: A Case Report.

A 53-year-old right-hand-dominant man presented with a recurrent, painful mass localized to the volar surface of the right small finger, leading to discomfort and impaired function. Radiographic imaging was unremarkable for osseous involvement. Surgical excision followed by histopathological and immunohistochemical (IHC) analysis established the diagnosis of angioleiomyoma, marked by desmin-positive smooth muscle fibers and CD34-positive vasculature.

Detection of clinically actionable gene fusions by next-generation sequencing-based RNA sequencing of non-small cell lung cancer cytology specimens: A single-center experience with comparison to fluorescence in situ hybridization.

Background: Genomic profiling is needed to identify actionable alterations in non-small cell lung cancer (NSCLC). Panel-based testing such as next-generation sequencing (NGS) is often preferred to interrogate multiple alterations simultaneously. In this study, we evaluate the utility of an RNA-based NGS assay to detect genomic alterations in NSCLC cytology specimens and compare these results to fluorescence in situ hybridization (FISH) testing.

Ephrin-A1 and the sheddase ADAM12 are upregulated in COVID-19.

More than 3.5 million people have died globally from COVID-19, yet an effective therapy is not available. It is, therefore, important to understand the signaling pathways that mediate disease progression in order to identify new molecular targets for therapeutic development.