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Histiocytic sarcomas are rare in humans and primates. Particularly, only a few examples in nonhuman primates have been reported. This is the first report of histiocytic sarcoma in Macaca fuscata. The final diagnosis was made using immunohistochemical analysis.
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http://dx.doi.org/10.1111/jmp.70028 | DOI Listing |
Cureus
August 2025
Department of Pathology, Saint Savvas Anticancer Hospital of Athens, Athens, GRC.
Histiocytic sarcoma is a rare malignancy composed of neoplastic cells that resemble macrophages in morphology and immunoprofile. It manifests in lymph nodes or extranodal sites, with the majority occurring in the gastrointestinal tract, central nervous system, spleen, skin, and soft tissues. Clinical manifestations depend on organ involvement, with systemic symptoms, including fever, fatigue, night sweats, weight loss, and weakness.
View Article and Find Full Text PDFActa Vet Scand
September 2025
Department of Animal Sciences (DCA), Federal University of the Semi-Arid Region - UFERSA, Avenida Francisco Mota, 572, Costa e Silva, Mossoró, 59625-900, RN, Brazil.
Background: Research on cancer in wild animals provides important insights into the mechanisms of carcinogenesis. Histiocytic sarcomas comprise a rare malignant macrophage-dendritic cell lineage neoplasm in wildlife. This study reports a case of histiocytic sarcoma in the small intestine of a collared peccary (Pecari tajacu), describing its clinical, anatomopathological, and immunohistochemical aspects.
View Article and Find Full Text PDFWorld J Clin Cases
October 2025
General Surgery Center, General Hospital of Western Theater Command, Chengdu 610083, Sichuan Province, China.
Splenic histiocytic sarcoma (SHS) is a rare, aggressive hematological malignancy with unclear progression and management. Our case illustrates the progression and pathophysiological processes of SHS and provides key data for the diagnosis, treatment and management of SHS. A 60-year-old female with incidentally detected splenic mass (6.
View Article and Find Full Text PDFVirchows Arch
August 2025
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072, Milan, Pieve Emanuele, Italy.
Malignant histiocytoses are rare histiocytic neoplasms that exhibit aggressive clinical and histopathological features. One of these entities, Langerhans cell sarcomas (LCS), shares some histopathological features with Langerhans cell histiocytosis but is distinguished by its overtly malignant cytologic features. The literature on LCS is mostly limited to short reports and a few reviews, while a complete revision of its nosology is lacking.
View Article and Find Full Text PDFInt J Surg Pathol
August 2025
Department of Pathology, Division of Hematopathology, the University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, and Jackson Memorial Hospital, Miami, FL, USA.
Rosai-Dorfman disease is an uncommon histiocytic neoplasm that is often self-limiting; however, rarely, it exhibits aggressive behavior and may undergo biological transformation to histiocytic sarcoma. Pathogenic genetic drivers of Rosai-Dorfman disease include recurrent genetic abnormalities in , , and Mutation of is a well-known oncogenic driver in histiocytic neoplasms, including up to 50% of Langerhans cell histiocytosis lesions, Erdheim-Chester disease, and adult and juvenile xanthogranuloma. However, mutations have been documented in only 4 reported Rosai-Dorfman disease specimens, and none were rearrangements.
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