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Background: Low back pain (LBP) is a prevalent condition that affects a significant portion of the population, leading to substantial healthcare costs and impact on quality of life. Effective management of LBP requires robust outcome measures to assess the efficacy of various treatment modalities.
Objective: This systematized review aimed to identify and evaluate the outcome measures used in the management of low back pain, focusing on their validity, reliability, sensitivity, and clinical relevance.
Methods: A comprehensive search of electronic databases, including PubMed, was conducted to identify studies that assessed the measurement properties of outcome measures used in the management of LBP. Data extraction focused on the types of outcome measures used and their psychometric properties. Data analysis was done after quantitatively pooling based on COSMIN guidelines.
Results: The database search and reference check resulted in 808 unique abstracts, of which 240 were assessed for full text eligibility. Ultimately, 124 articles describing 56 unique PROM's measuring different proposed domains were included in this systematized review. The review identified a range of outcome measures employed in LBP management under each proposed domain based on the millennial recommendations. This review also mentioned several new outcome measures such as Physical activity decline (PAD) score, Backache Disability Index (BADIX), Working Alliance Inventory (WAI), return-to-work self-efficacy (RTWSE-19) questionnaire, The NIH task force's minimum data set and World Health Organisation Disability Assessment Schedule (WHODAS 2.0) with sufficient measurement properties. This review highlighted gaps in the sensitivity of some measures to detect clinically meaningful changes and emphasized the need for standardization in outcome reporting.
Interpretation And Conclusion: Effective management of LBP relies on the use of validated and reliable outcome measures. While traditional PROM's like the ODI and RMDQ remain prevalent, emerging tools may offer enhanced sensitivity and comprehensiveness. Future research should aim to standardize outcome measures and assess their psychometric properties to facilitate comparisons across studies and improve the quality of evidence in LBP management.
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http://dx.doi.org/10.1002/msc.70161 | DOI Listing |
Stroke
September 2025
Department of Neurology, Yale School of Medicine, New Haven, CT (L.H.S.).
Preclinical stroke research faces a critical translational gap, with animal studies failing to reliably predict clinical efficacy. To address this, the field is moving toward rigorous, multicenter preclinical randomized controlled trials (mpRCTs) that mimic phase 3 clinical trials in several key components. This collective statement, derived from experts involved in mpRCTs, outlines considerations for designing and executing such trials.
View Article and Find Full Text PDFRev Med Liege
September 2025
Service de Pneumologie, CHU Liège, Belgique.
Severe emphysema impairs lung function and quality of life in patients with Chronic Obstructive Pulmonary Disease (COPD). Despite optimized medical treatment and rehabilitation, some patients require lung volume reduction interventions (endoscopic or surgical). This study evaluates one-year outcomes of patients managed at the Emphysema Clinic of CHU Liège.
View Article and Find Full Text PDFAnn Med
December 2025
Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Background: Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine carcinoma (NEC) with poor prognosis due to chemotherapy resistance. Molecular subtypes, including ASCL1, NEUROD1, YAP1 and POU2F3, have distinct clinical implications. POU2F3, linked to a tuft cell-like lineage, represents a non-neuroendocrine subtype found in SCLC and extrapulmonary NECs.
View Article and Find Full Text PDFCNS Neurosci Ther
September 2025
Department of Functional Neurosurgery, Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Aim: A total of 30% of individuals with epilepsy are resistant to drug treatment. Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) shows promise for treating drug-resistant epilepsy (DRE), but further research is needed to optimize DBS parameters, including stimulation frequency. This study aimed to reveal the optimal frequency for ANT-DBS by testing the real-time effects of various stimulation frequencies on the ANT among patients undergoing stereoelectroencephalography (SEEG) electrode implantation.
View Article and Find Full Text PDFPalliat Support Care
September 2025
REHPA, The Danish Knowledge Centre for Rehabilitation and Palliative Care, Odense University Hospital, Nyborg, Denmark.
Objectives: This study aimed to investigate healthcare professionals' experiences with using the PRO Palliative Care questionnaire (PRO-Pall) to identify palliative care symptoms and problems in non-specialized palliative care settings among patients with heart, lung, and kidney disease, and cancer. The study also investigated the PRO-Pall's potential to ensure further initiatives and care.
Methods: A national, multicenter, observational study employing a mixed-methods approach.