Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Single-cell omics data analyses are complicated to design and difficult to distribute or reproduce. We present a web platform that enables no-code analysis pipeline design, computing, and the sharing of entire data analysis pipelines, their input data, and interactive results as a unit. We expect this platform to improve the accessibility and reproducibility of single-cell omics.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.jproteome.5c00178 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The X-Age Project to construct a Chinese aging clock.
Nat Aging
September 2025
Aging Biomarker Consortium (ABC), Beijing, China.
The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age-related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual's physiological and molecular state, across diverse Chinese cohorts.
View Article and Find Full Text PDFTestis-specific protein HSF5 is essential for proper chromatin organization and transcriptional reprogramming to drive pachynema progression.
Zool Res
September 2025
Department of Urology & Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China. E-mail:
Chromatin remodeling and transcriptional reprogramming play critical roles during mammalian meiotic prophase I; however, the precise mechanisms regulating these processes remain poorly understood. Our previous work demonstrated that deletion of heat shock factor 5 (HSF5), a member of the heat shock factor family, induces meiotic arrest and male infertility. However, the molecular pathways through which HSF5 governs meiotic progression have not yet been fully elucidated.
View Article and Find Full Text PDFScvi-hub: an actionable repository for model-driven single-cell analysis.
Nat Methods
September 2025
Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA.
The growing availability of single-cell omics datasets presents new opportunities for reuse, while challenges in data transfer, normalization and integration remain a barrier. Here we present scvi-hub: a platform for efficiently sharing and accessing single-cell omics datasets using pretrained probabilistic models. It enables immediate execution of fundamental tasks like visualization, imputation, annotation and deconvolution on new query datasets using state-of-the-art methods, with massively reduced storage and compute requirements.
View Article and Find Full Text PDFIdentifying potential therapeutic targets in periodontitis: a multi-omics approach integrating bulk and single-cell RNA sequencing with Mendelian randomization.
Naunyn Schmiedebergs Arch Pharmacol
September 2025
School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Periodontal disease (PD) is a common and complex oral health problem that affects teeth and gums, leading to tooth loss, misalignment, and infection, with significant impact. Identifying the cause and developing new treatments is crucial. This study employed Mendelian randomization (MR), single-cell RNA sequencing (scRNA-seq), and integrated transcriptomics to identify key gene signatures associated with periodontitis.
View Article and Find Full Text PDFBridging Planarian Bioassays and AOP-Based Environmental Assessment: Toward Mechanistic Insights into Pollutant-Induced Disruptions.
Environ Res
September 2025
School of Geography, Earth & Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom. Electronic address:
Human activities have introduced a wide range of contaminants into aquatic ecosystems, posing substantial ecological and health risks. Robust bioindicators are essential for accurately predicting these impacts. Since the early 1980s, planarians-freshwater flatworms known for their remarkable regenerative ability and neurologically relevant system-have been used in ecotoxicology, witnessing renewed scientific interest post-2010.
View Article and Find Full Text PDF