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This paper introduces a novel 13-level switched capacitor inverter. The proposed structure, comprising ten switches, five diodes, one input DC source, and five capacitors, can generate an alternating output voltage with a sixfold increase in the output load. The reduced number of switches lowers the cost of gate drivers, reducing the converter's volume and increasing its power density. Additionally, it requires only five separate control signals, simplifying the control process. In addition to the advantage of six times voltage boosting and a low switch count, the capacitors' automatic voltage balancing is considered a significant benefit for the proposed inverter. Also, the ripple and capacitor charging spike have been reduced by implementing a phase-shift modulation hybrid with an additional switching state. The circuit description, operating principles, hybrid pulse width modulation method, capacitor voltage ripple, and determination of the current-limiting inductor value and losses have been analyzed. The proposed structure has been compared with similar structures, and the performance of the proposed inverter has been assessed using simulation results, which experimental results have validated.
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http://dx.doi.org/10.1038/s41598-025-13381-w | DOI Listing |
Mem Cognit
September 2025
Department of Psychology, University of York, York, YO10 5DD, UK.
Language control has been argued to adapt dynamically to the language context bilinguals are communicating in (Green & Abutalebi, 2013). Previous research has suggested that the demands of the task and current context itself can influence a bilingual's language behaviour and potentially also their language control. Here, we examined how the preceding context, specifically the switching patterns of another bilingual in that context, can influence a bilingual's own language control during production.
View Article and Find Full Text PDFNat Plants
September 2025
Plant Science Division, Research School of Biology, The Australian National University, Canberra, Australian Capital Territory, Australia.
A new Escherichia coli laboratory evolution screen for detecting plant ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) mutations with enhanced CO-fixation capacity has identified substitutions that can enhance plant productivity. Selected were a large subunit catalytic (Met-116-Leu) mutation that increases the k of varying plant Rubiscos by 25% to 40% and a solubility (Ala-242-Val) mutation that improves plant Rubisco biogenesis in E. coli 2- to 10-fold.
View Article and Find Full Text PDFDig Liver Dis
September 2025
Division of Pediatric Gastroenterology and Nutrition, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer, Israel; The Gray Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel; Cincinnati Children's Hospital Medical Center and the University of Cin
Background And Aims: The development of antibodies to infliximab (ATI) is a major challenge in pediatric inflammatory bowel disease (IBD). This real-world study aimed to identify predictors of ATI, evaluate strategies to overcome ATI, and compare the durability of continuing infliximab (IFX) versus switching to adalimumab (ADA) after ATI development.
Methods: We retrospectively analyzed 194 pediatric IBD patients treated with IFX from 2010 to 2024.
Cancer Lett
September 2025
State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Tianjian Laboratory of Advanced Biomedical Sciences, Department of Radiology, Department of Clinical Research and Translational Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou,
The tumor microenvironment (TME) plays a pivotal role in cancer progression, though the molecular regulators governing its immunosuppressive properties remain incompletely characterized. In this study, we identify Makorin-2 (MKRN2) as a novel modulator of TME remodeling through integrated analyses of genetically engineered mouse models and human clinical data. Utilizing MKRN2 knockout mice, we observed significantly accelerated tumor growth compared to wild-type control, which was associated with profound alterations in immune cell composition, especially M2 macrophages.
View Article and Find Full Text PDFAnal Chem
September 2025
School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo 255049, PR China.
Pax-5a gene, as a nucleic acid biomarker closely associated with B-cell acute lymphoblastic leukemia (B-ALL), holds significant potential for early disease diagnosis. In this study, we developed a highly accurate and efficient "on-super on-off" photoelectrochemical (PEC) biosensor based on a dual-photoelectrode heterojunction system integrated with a multisphere cascade DNA amplification strategy. The designed heterojunction dual-photoelectrode platform, comprising a InO/CdS photoanode (on state) and an in situ-formed MIL-68(In)/InO (MIO) photocathode, effectively extends the electron-hole transport pathway, enhances photogenerated charge separation, and produces high-amplitude signal output (super on state), thereby providing a robust baseline for signal transduction.
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