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http://dx.doi.org/10.1016/j.jacc.2025.05.038 | DOI Listing |
Lancet Rheumatol
September 2025
Bristol Royal Hospital for Children and Translational Health Sciences, Bristol, UK. Electronic address:
Background: Baricitinib has previously been shown to improve clinical response in patients with juvenile idiopathic arthritis (JIA) in the JUVE-BASIS trial. In this post-hoc analysis we aimed to identify whether pharmacodynamic changes in serum biomarkers in response to baricitinib treatment could help reaffirm the clinical utility of baricitinib in patients with JIA.
Methods: JUVE-BASIS was a randomised, double-blind, placebo-controlled, withdrawal, efficacy, safety, phase 3 trial, done in 75 centres in 20 countries.
Lancet Oncol
September 2025
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Genitourinary Oncology, Peking University Cancer Hospital & Institute, Beijing, China. Electronic address:
Background: The underexplored potential of PD-L1 blockade in advanced renal cell carcinoma highlights an urgent need for novel agents. This trial aimed to compare benmelstobart (a novel PD-L1 inhibitor) plus anlotinib with sunitinib as first-line treatment for advanced renal cell carcinoma.
Methods: ETER100 was a multicentre, randomised, open-label, phase 3 trial conducted at 37 medical sites in China.
BMC Geriatr
September 2025
Department of Motor Behavior and Sport Management, Faculty of Sports Science, Urmia University, Urmia, Iran.
Background: Knee osteoarthritis (KOA) is a prevalent condition among older adults, leading to impaired proprioception and reduced gait speed, which compromise mobility and quality of life. While aquatic therapy and transcranial direct current stimulation (tDCS) have individually shown potential for enhancing motor and sensory functions, their combined effects are not well understood.
Objective: This study aimed to evaluate the combined effects of aquatic therapy and tDCS on knee proprioception and gait speed in older women with KOA.
Nicotine Tob Res
August 2025
NFL Biosciences, Castelnau-Le-Lez, France.
Introduction: Tobacco addiction remains a major public health challenge. Existing smoking cessation treatments require prolonged daily use with potentially poor adherence and reduced efficacy.
Methods: The phase II study was a multicenter, randomized, double-blind, placebo-controlled trial with a one-year follow-up to assess the efficacy, safety, and immunogenicity of NFL-101 as a potential aid for smoking cessation.
Psychopharmacology (Berl)
August 2025
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, J5/68159, Mannheim, Germany.
Rationale: Negative affect is a key factor in Alcohol Use Disorder (AUD) associated with craving and relapse risk that is insufficiently treated by approved medications. Cannabidiol (CBD) has shown promising effects on negative affect, indicating its potential for addressing the neurocircuitry underlying negative affect in AUD.
Objectives: This study investigates CBD's effects on neural response to negative emotional stimuli and subjective alcohol craving in individuals with AUD.