Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Understanding genetic variation is necessary to unravel the complexities of evolution and diverse traits across species. Short genetic variants (<50 bp in length) represent key genomic variations that play a crucial role in shaping the genetic landscape of populations. Human short genetic variant databases are often considered the gold standard for variant repositories, and this review compares them with variant databases created for various animal species. This review examines the methodologies, data integration, and various applications that differ or align between human and animal databases. The goal is to identify challenges in leveraging genetic variation across species, recommend strategies for overcoming these challenges, and suggest future directions for research and database development.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309242 | PMC |
| http://dx.doi.org/10.1093/bib/bbaf356 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Inflammatory gene expression profile of oral plasmablastic lymphoma.
Virchows Arch
September 2025
Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Minas Gerais, Av. Antônio Carlos, Pampulha, Belo Horizonte, 31270-901, Brazil.
Plasmablastic lymphoma (PBL) is a rare and aggressive non-Hodgkin lymphoma with a poor prognosis and short survival rates. It is classified as a large B-cell lymphoma subtype, but carries a plasmacytic immunophenotype. Therefore, PBL has pathogenetic overlaps with diffuse large B-cell lymphoma not otherwise specified (DLBCL NOS) and plasma cell neoplasms (PCNs).
View Article and Find Full Text PDFAn immunocompetent mouse model of metastatic triple-negative breast cancer.
Methods Cell Biol
September 2025
LR18ES03 Laboratory of Neurophysiology, Cellular Physiopathology and Valorisation of Biomolecules, Faculty of Science of Tunis, University Tunis El Manar, Tunis, Tunisia. Electronic address:
Breast cancer (BC) represents a major socio-economic challenge worldwide due to its high morbidity and mortality rates. Despite various therapeutic strategies, the heterogeneity of breast cancer and the resistance of tumour cells often lead to treatment failure. Consequently, the use of animal models of BC is crucial for understanding the cellular and molecular mechanisms involved in the different stages of carcinogenesis and for screening new drugs to assess their efficacy, potential safety and side effects.
View Article and Find Full Text PDFPaws for a moment: Investigation of bi-directional transfer of human DNA during a short human-dog interaction and subsequent indirect transfers.
Sci Justice
September 2025
College of Science and Engineering, Flinders University, Bedford Park, South Australia, Australia.
DNA transfer events have been well researched in the context of commonly found items at crime scenes. However, whilst animals are a common feature of most households, transfer events involving companion animals have been understudied. Recent research has shown that dogs and cats are a reservoir of human DNA that can transfer to a hand or sterile object after a short contact.
View Article and Find Full Text PDFDiscriminatory power of the Precision ID GlobalFiler™ NGS STR panel v2 in monozygotic twins for forensic applications.
Sci Justice
September 2025
Departamento de Medicina Legal, Bioética, Medicina do Trabalho e Medicina Física e Reabilitação, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address:
Short Tandem Repeats (STRs) are the standard technique used in forensic genetics for individual identification due to their high polymorphism and robustness. Although Capillary Electrophoresis (CE) enables the analysis of many STRs, Next-Generation Sequencing (NGS) offers enhanced resolution and the ability to detect STRs' isoalleles and their flanking regions, enhancing the discrimination power of this analysis. Despite the fact that STR kits for NGS are well standardized for evaluating forensic samples, there is no data on their effectiveness in differentiating monozygotic (MZ) twins, which are indistinguishable by CE.
View Article and Find Full Text PDFEASY-edit: a toolbox for high-throughput single-step custom genetic editing in bacteria.
Nucleic Acids Res
September 2025
Expression génétique microbienne, UMR8261 CNRS, Université Paris Cité, Institut de Biologie Physico-Chimique, Paris 75005, France.
Targeted gene editing can be achieved using CRISPR-Cas9-assisted recombineering. However, high-efficiency editing requires careful optimization for each locus to be modified, which can be tedious and time-consuming. In this work, we developed a simple, fast and cheap method: Engineered Assembly of SYnthetic operons for targeted editing (EASY-edit) in Escherichia coli.
View Article and Find Full Text PDF