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Background Clinical nephropathy is a prevalent and serious microvascular complication of type 2 diabetes mellitus (T2DM), contributing substantially to increased morbidity and mortality among affected individuals. It often progresses insidiously, leading to end-stage renal disease if not promptly detected and managed. Despite its growing public health importance, there is a paucity of region-specific data on the prevalence and correlates of clinical nephropathy in patients with T2DM, particularly in resource-limited settings. In regions such as Abia State, Nigeria, limited research has been conducted to determine the burden of diabetic nephropathy and its clinical correlates. Understanding the local epidemiology of this complication is essential for guiding early detection strategies, optimizing management, and improving patient outcomes. Objective This study investigates the prevalence and correlates of clinical nephropathy among patients with type 2 diabetes at Abia State Specialist Hospital and Diagnostic Center, Nigeria, to inform strategies for improving early detection and management of diabetic nephropathy complications. Methodology A cross-sectional study design was employed at the Abia State Specialist Hospital and Diagnostic Center outpatient clinic. The sample size ( = 255) was calculated using the Cochran formula, considering a known prevalence of nephropathy in patients with T2DM in Nigeria. Data were collected through structured interviews, clinical examinations, and laboratory procedures, and analyzed using IBM SPSS Statistics for Windows, Version 20 (IBM Corp., Armonk, NY). Results Clinical information indicated a high prevalence of clinical nephropathy (77, 30.20%). Lifestyle factors reflected low tobacco use (25, 9.80%) and alcohol consumption (32, 12.55%), with frequent engagement in physical activity (87, 34.12%). Access to healthcare revealed barriers (174, 68.24%) and limited knowledge of diabetic kidney disease (77, 30.20%). Anthropometric indices and blood pressure showed significant differences between groups ( < 0.05), with diabetic patients with nephropathy exhibiting higher values. Renal indices also displayed significant differences ( < 0.05), indicating renal dysfunction among diabetic patients with nephropathy. The prevalence of albuminuria was notable (microalbuminuria: 156, 61.18%). The staging of clinical nephropathy revealed varying severity levels. Conclusions The clinical nephropathy prevalence among patients with T2DM at Abia State Specialist Hospital and Diagnostic Center, Umuahia, Nigeria, is substantial. Factors such as anthropometric indices, blood pressure, renal parameters, glycemic control, and lipid profiles significantly correlate with the presence of nephropathy. These findings underscore the importance of early detection and management strategies to mitigate diabetic nephropathy complications.
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http://dx.doi.org/10.7759/cureus.86962 | DOI Listing |
PLoS One
September 2025
Chilean Invasive Mycosis Network, Santiago, Chile.
Background: Invasive mold diseases (IMDs) are a severe complication of immunocompromised subjects and an emerging problem among severely ill, apparently immunocompetent patients. The aim of this study was to describe the epidemiological and clinical features of IMDs in Chile.
Methods: Prospective study of IMD cases in children and adults from 11 reference hospitals in Chile from May 2019 to May 2021.
Background: Acute kidney injury (AKI) in patients with liver cirrhosis represents a significant clinical challenge with high mortality rates. This study aimed to develop and validate a machine learning-based prediction model for 28-day mortality in AKI patients with liver cirrhosis using the MIMIC-IV database.
Methods: This retrospective study analyzed data from 4,168 AKI patients, including 601 with concurrent liver cirrhosis, from the MIMIC-IV database.
Nephrol Dial Transplant
September 2025
Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Background: We investigated circulating protein profiles and molecular pathways among various chronic kidney disease (CKD) etiologies to study its underlying molecular heterogeneity.
Methods: We conducted a proteomic biomarker analysis in the DAPA-CKD trial recruiting adults with and without type 2 diabetes with an eGFR of 25 to 75 mL/min/1.73m2 and a UACR of 200 to 5000 mg/g.
JAMA Netw Open
September 2025
Division of Cardiology, Department of Internal Medicine, New Taipei Municipal TuCheng Hospital, New Taipei, Taiwan.
Importance: The cardiovascular benefits of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may vary by body mass index (BMI), but evidence on BMI-specific outcomes remains limited.
Objective: To investigate the associations of GLP-1 RA use with cardiovascular and kidney outcomes across BMI categories in patients with type 2 diabetes.
Design, Setting, And Participants: This retrospective cohort study used the Chang Gung Research Database, a clinical dataset covering multiple hospitals in Taiwan.
BioDrugs
September 2025
Department of Nephrology, Instituto de Investigación Hospital "12 de Octubre" (imas12), Avda. De Córdoba s/n, 28041, Madrid, Spain.
Anti-CD20 monoclonal antibodies are gaining clinical relevance in the nephrology community due to their demonstrated efficacy and favorable safety profiles across short-, medium-, and long-term use. Initially developed for hematologic malignancies and multiple sclerosis, B-cell depletion therapies are now being investigated across a broader spectrum of autoimmune diseases, including glomerulopathies, both with and without associated podocytopathy. Recent advances have led to the development of novel anti-CD20 agents that are being used not only as potential alternatives to corticosteroids but also as adjunctive therapies in complex clinical settings.
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