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Introduction: Teaching innovation (TI) is crucial with respect to efforts to cultivate innovative talent and enhance national competitiveness. To promote TI, the Chinese government has issued policy documents that have emphasized the need to overcome the traditional management model, which focuses on the "principal's individual heroism," and to encourage schools to implement distributed leadership (DL) with the goal of achieving multiparty cogovernance. However, few studies have investigated whether and how the implementation of DL in the centralized and bureaucratic management models used in China can foster TI among teachers.
Methods: To address this gap, this study examines 3,976 teachers working at the lower secondary level in Shanghai, China, on the basis of data obtained from the 2018 Teaching and Learning International Survey (TALIS) dataset; in this context, a structural equation model (SEM) is used to compare a parallel mediation model constructed by reference to self-determination theory (SDT) with a chain mediation model constructed through the integration of SDT with conservation of resources theory (COR).
Results: The results of this research reveal the superiority of the chain mediation model, according to which two independent mediation paths pertaining to teacher collaboration (TC) and teacher self- efficacy (TSE), as well as the two chain mediation paths of TC → TSE and teacher autonomy (TA) → TSE, are significant with respect to the relationship between DL and TI.
Discussion: Theoretically, this study clarifies the mechanism underlying the influence of DL on TI in collectivist cultures; practically, it provides a reference for management practice for lower secondary school teachers with respect to TI.
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http://dx.doi.org/10.3389/fpsyg.2025.1562838 | DOI Listing |
Acta Neuropathol Commun
September 2025
Department of Biomedical and Clinical Sciences and Department of Clinical Pathology, Linköping University, 58185, Linköping, Sweden.
Disruptions in synaptic transmission and plasticity are early hallmarks of Alzheimer's disease (AD). Endosomal trafficking, mediated by the retromer complex, is essential for intracellular protein sorting, including the regulation of amyloid precursor protein (APP) processing. The VPS35 subunit, a key cargo-recognition component of the retromer, has been implicated in neurodegenerative diseases, with mutations such as L625P linked to early-onset AD.
View Article and Find Full Text PDFJ Biomed Sci
September 2025
Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Background: PPM1D (protein phosphatase Mg⁺/Mn⁺ dependent 1D) is a Ser/Thr phosphatase that negatively regulates p53 and functions as an oncogenic driver. Its gene amplification and overexpression are frequently observed in various malignancies and disruption of PPM1D degradation has also been reported as a cause of cancer progression. However, the precise mechanisms regulating PPM1D stability remain to be elucidated.
View Article and Find Full Text PDFBMC Nurs
September 2025
Department of Nursing Administration, Faculty of Nursing, Alexandria University, Alexandria, Egypt.
Background: Organizational virtuousness and just culture, which both foster justice, honesty, and trust, have a major impact on positive work environments in the healthcare industry. Strengthening nurses' emotional engagement and vocational commitment requires these components. With an emphasis on the mediating function of just culture, this study attempts to investigate the relationship between organizational virtuousness and nurses' vocational commitment.
View Article and Find Full Text PDFStem Cell Rev Rep
September 2025
Paris Cité University, INSERM UMR-S 970, Paris Cardiovascular Research Centre, Paris, France.
Endothelial Colony-Forming Cells (ECFCs) are recognized as key vasculogenic progenitors in humans and serve as valuable liquid biopsies for diagnosing and studying vascular disorders. In a groundbreaking study, Anceschi et al. present a novel, integrative strategy that combines ECFCs loaded with gold nanorods (AuNRs) to enhance tumor radiosensitization through localized hyperthermia.
View Article and Find Full Text PDFMol Psychiatry
September 2025
Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Pharmacological modulation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) through dual GIP/GLP-1 receptor agonists, commonly used for diabetes and obesity, shows promise in reducing alcohol consumption. We applied drug-target Mendelian randomization (MR) using genetic variation at these loci to assess their long-term effects on problematic alcohol use (PAU), binge drinking, alcohol misuse classifications, liver health, and other substance use behaviors. Genetic proxies for lowered BMI, modeling the appetite-suppressing and weight-reducing effects of variants in both the GIPR and GLP1R loci ("GIPR/GLP1R"), were linked with reduced binge drinking in the primary (β = -0.
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