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This study examines how Chinese EFL learners behave in peer interactions by negotiating meaning through communication strategies. This is a small-scale study with both quantitative and qualitative analysis. Sixteen Chinese EFL students and one native English teacher were observed in an intensive English program. The students were asked to interact with their peers in a decision-making task and an information-gap task. Video-recorded data were collected, transcribed and analyzed. The results showed that negotiation occur more frequently in information-gap tasks than decision-making tasks and students primarily employed confirmation checks. For communication strategies used to negotiate, direct strategies were employed most frequently, in which students mainly used code-switch and mime. Indirect strategies followed, with repetition occurring as the most frequently employed strategy. Interactional strategies, including co-construction and appeal for help, were less frequently used. The findings highlight the influence of cultural factors and students' motivation on their behaviors.
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http://dx.doi.org/10.3390/bs15070976 | DOI Listing |
Mol Cancer Ther
September 2025
Case Western Reserve University School of Medicine, Cleveland, OH, United States.
The estrogen receptor (ER or ERα) remains the primary therapeutic target for luminal breast cancer, with current treatments centered on competitive antagonists, receptor down-regulators, and aromatase inhibitors. Despite these options, resistance frequently emerges, highlighting the need for alternative targeting strategies. We discovered a novel mechanism of ER inhibition that targets the previously unexplored interface between the DNA-binding domain (DBD) and ligand-binding domain (LBD) of the receptor.
View Article and Find Full Text PDFChild Care Health Dev
September 2025
Department of Behavioral Sciences and Learning, Linköping University, Linköping, Sweden.
Objective: To describe the self-report instruments used to measure well-being in children with disabilities, investigate their psychometric quality, cognitive accessibility and alignment with Keyes's operationalization of well-being, including emotional, psychological and social aspects.
Methods: MEDLINE, ProQuest, PubMed and CINAHL were searched for articles published from 2011 to March 2023, identifying 724 studies. Synonyms provided by thesaurus on the main constructs: 'children', 'measure', 'disability' and 'mental health' were employed in the search strategy.
Neuroinflammation has emerged as a central and dynamic component of the pathophysiology underlying a wide range of neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis. Far from being a secondary consequence of neuronal damage, inflammatory processes (mediated by microglia, astrocytes, peripheral immune cells, and associated molecular mediators) actively shape disease onset, progression, and symptomatology. This review synthesizes current knowledge on the cellular and molecular mechanisms that govern neuroinflammatory responses, emphasizing both shared and disease-specific pathways.
View Article and Find Full Text PDFPublic Health Nutr
September 2025
Edge Hill University, Faculty of Health, Social Care and Medicine, Ormskirk, United Kingdom.
Objective: The food system is a major contributor to the global burden of disease, ecosystem destruction and climate change, posing considerable threats to human and planetary health and economic stability. Evidence based food policy is fundamental to food system transformation globally, nationally and at a local or institutional level. The study aimed to critically review the content of universities' food sustainability (FS) policy documents.
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