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Articular cartilage is difficult to regenerate. It often leads to osteoarthritis after injury, which seriously affects the quality of life of patients. Presently, the clinical treatments of articular cartilage injury have certain limitations. With the development of tissue engineering, cartilage repair becomes possible. Different types of bionic scaffolds have shown great application potential in cartilage repair. We reviewed the characteristics of ideal bionic scaffolds, including biocompatibility, biodegradability, mechanical and structural properties, bioactivity and functionality. We also summarized the latest research progress of different bionic scaffolds in recent years, hoping to provide a reference for the design of bionic scaffolds with stable performance and definite efficacy, and help them to be gradually applied in clinical practice.
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http://dx.doi.org/10.3389/fbioe.2025.1625550 | DOI Listing |
Anal Chim Acta
November 2025
Institute of Materials Science, Vietnam Academy of Science and Technology, Hanoi, 10000, Viet Nam. Electronic address:
Background: Recent advancements in cancer therapeutics have catalyzed the development of noninvasive treatment modalities, including the utilization of fluorescent chemotherapeutic agents. These agents offer dual functionality, enabling targeted drug delivery, real-time tumor imaging, and personalized therapy monitoring. Such capabilities are instrumental in the progression toward more precise and effective cancer interventions.
View Article and Find Full Text PDFJ Hazard Mater
September 2025
State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu 610500, PR China; College of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu 610500, PR China; Oil & Gas Field Applied Chemistry Key Laboratory of Sichuan Provi
The increasing discharge of complex wastewater, which poses a significant risk to the environment and health, requires the development of an efficient and versatile treatment technology. In this study, we present a more environmentally friendly bifunctional membrane made by in-situ hydrothermal growth of metal-organic frameworks (MOFs) on electrospun nanofibers that can be used for the simultaneous removal of emulsified oils and heavy metal ions. The electrostatically spun fiber substrate consisting of polyacrylonitrile (PAN) and polyimide (PI) provided a high surface scaffold for the uniform deposition of gallic acid biobased MOFs, which ensured highly efficient adsorption and filtration properties as well as the advantage of facilitating secondary recycling.
View Article and Find Full Text PDFFront Mol Biosci
August 2025
Department of Basic Medical Sciences, Faculty of Medical Sciences and Health Sciences, Casimir Pulaski University of Radom, Radom, Poland.
Background: Electrospun nanofibers, which are becoming increasingly popular in biomedicine, can directly or indirectly affect the properties and formation of the edothelial layer. This effect can be both toxic and pro-stimulatory. Therefore, in this study, electrospun nanofibers PLCL/PVP composed of biodegradable and biocompatible L-lactide-block--caprolactone copolymer (PLCL, 70:30) blended with polyvinylpyrrolidone (PVP), containing synthesized PVP different types of nanoparticles - gold (AuNPs), cadmium selenide (CdSe QDs) or tantalum (TaNPs), were investigated.
View Article and Find Full Text PDFFEBS J
August 2025
Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary.
Guanylate kinase-associated protein (GKAP) is a large postsynaptic scaffold protein bearing two closely spaced noncanonical binding sites for the bivalent dynein light chain LC8 hub protein. This might allow the formation of heterogeneous complexes with different sizes and topologies. Here, we show that a well-defined hexameric complex is formed, composed of two GKAP molecules and two LC8 dimers.
View Article and Find Full Text PDFAdv Healthc Mater
August 2025
Centre for Oral, Clinical, and Translational Sciences, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, SE1 9RT, UK.
Biomimetic protein-based platforms, with their hierarchical networks and optimal mechanical properties, show promising potential for hard tissue regeneration, including dental enamel. However, achieving aligned enamel-like apatite nanocrystals from organic matrices remains challenging. A simple organic-based approach to re-create the hierarchical enamel structure using water-based keratin films is reported.
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