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Introduction: Seasonal hyperacute panuveitis (SHAPU) is still a dilemma in the field of ophthalmology. Every alternate odd year from September until January, children usually present with unilateral painless red eyes if not treated in a timely manner, rapidly progressing to phthisis bulbi.
Case: Case was also diagnosed as a case of seasonal hyperacute panuveitis.
Observations: However, during the treatment, the patient developed spontaneous scleral necrosis, which has not been reported to date.
Conclusion: Seasonal hyperacute panuveitis may have different clinical presentation, therefore cases of seasonal hyperacute panuveitis should be monitored and evaluated properly before initiating treatment.
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http://dx.doi.org/10.3126/nepjoph.v16i1.59410 | DOI Listing |
BMC Ophthalmol
August 2025
B.P. Eye Foundation, Children's Hospital for Eye, ENT and Rehabilitation Services, Bhaktapur, Nepal.
Purpose: Seasonal Hyperacute Panuveitis (SHAPU) is a severe, rapid-onset panuveitis primarily affecting children, often linked to the setae released in the air or by contact with female moths of the genus Gazalina (Lepidoptera, Notodontidae), or with their egg masses laid on various substrates. This study aims to report a rare case of SHAPU from the higher altitude of Nepal with an alpine climate, with concurrence of necrotising scleritis. To the best of our knowledge, this is the first report of SHAPU at high elevation.
View Article and Find Full Text PDFOphthalmol Ther
August 2025
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Climate change and global warming significantly affect the incidence and distribution of infectious ocular diseases. This narrative review explores how climate-related factors-including extreme weather events, precipitation, temperature fluctuations, humidity, wind patterns, ultraviolet radiation, and air pollution-can directly and indirectly influence the burden of ocular infections. By synthesizing evidence from the published literature, we examine how these environmental variables impact disease mechanisms such as pathogen survival, transmission dynamics, and host susceptibility.
View Article and Find Full Text PDFJ Stroke Cerebrovasc Dis
August 2025
Department of Endocrinology, Ashford and St Peter's Hospitals NHS Foundation Trust, Guildford Road, Chertsey, Surrey KT16 0PZ, UK; Institute of Cardiovascular Research, Royal Holloway University of London, Egham, TW20 0EX, UK. Electronic address:
Objectives: How seasonal variations influence the incidence of fatal stroke remains unclear. Here, we examined potential mediators of the association between seasons and fatal strokes.
Methods: Data were prospectively collected (2014-2016) from the Sentinel Stroke National Audit Programme for admissions to four UK hyperacute stroke units.
Semin Ophthalmol
May 2025
Department of Ophthalmology, Hospital Universitario del Henares, Madrid, Spain.
Purpose: Ophthalmia nodosa is an inflammatory ocular condition caused by the penetration of arthropod hairs (setae) into the eye. This review aims to systematize current knowledge on the condition, identify knowledge gaps, and propose an updated classification.
Methods: A systematic literature review was conducted in July 2024 in PubMed and Cochrane Central.
Ocul Immunol Inflamm
July 2025
B.P. Eye Foundation, Hospital for Children Eye ENT and Rehabilitation Services (CHEERS), Bhaktapur, Nepal.
For the past 50 years, significant progress has been made in understanding Seasonal Hyperacute Panuveitis (SHAPU), a mysterious blinding disease first reported in Nepal in 1975. Predominantly affecting Nepalese children, SHAPU occurs cyclically every odd year from September to December. While initially misclassified as endophthalmitis, SHAPU is set apart by its lack of trauma or surgery, failure to grow organisms in most intraocular fluid cultures, and its hallmark presentation of a "white pupil in red eye" with an association with moth exposure.
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