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This study aimed to evaluate the effectiveness of early active mandibular exercise (AME) to address mouth-opening limitation following orthognathic surgery in patients with skeletal Class III malocclusion. This was a single-centre, randomised, controlled, and double-blinded experimental study. In 44 subjects, the experimental group (n = 21) performed AME 10 times daily and were asked to self-assess the degree of opening by counting the number of tongue depressors they could fit in, whereas the control group (n = 23) performed only basic finger exercises. Efficacy was assessed by the range of mandibular movement in four directions (maximum opening, and right lateral, left lateral, and anterior movements), and pain was assessed using a visual analogue scale. Opening-related quality of life (QoL) was assessed using a questionnaire. All variables were measured immediately (T0), and at one week (T1), two weeks (T2), four weeks (T3), and 12 weeks (T4) after the removal of intermaxillary fixation. Statistical analyses were performed using the Mann-Whitney U, Friedman, and chi-squared tests. The experimental group demonstrated earlier recovery of mandibular range of motion in all directions compared with the control group during T0-T1 (p < 0.05). The control group gradually recovered from T0-T4. At T1 the opening recovery rate was 56-68% in the experimental group and 18-39% in the control group. Pain scores were significantly lower in the experimental group than in the control group at T1 (p < 0.05). The experimental group also showed an earlier positive response to all daily living activities at T3 compared with T4 in the control group. AME not only effectively recovers mouth-opening limitation after orthognathic surgery, but also promotes early improvements in range of motion and pain scores. Furthermore, it is an effective intervention to facilitate an early return to the opening-related activities of daily living.
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http://dx.doi.org/10.1016/j.bjoms.2025.05.016 | DOI Listing |
Biomaterials
August 2025
Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA. Electronic address:
Wearable bioelectronics have transformed modern biomedical applications by enabling seamless integration with biological tissues, providing continuous, comprehensive, and personalized healthcare. Skin cancer, particularly melanoma, poses a significant clinical challenge due to its high metastatic potential and associated mortality. Traditional diagnostic approaches face limitations in accuracy, accessibility, and reproducibility, while existing treatments are often constrained by systemic toxicity and therapeutic resistance.
View Article and Find Full Text PDFJMIR Res Protoc
September 2025
Department of Medical Oncology, Early Phase Unit, Georges-François Leclerc Centre, Dijon, France.
Background: Sarcomas are rare cancer with a heterogeneous group of tumors. They affect both genders across all age groups and present significant heterogeneity, with more than 70 histological subtypes. Despite tailored treatments, the high metastatic potential of sarcomas remains a major factor in poor patient survival, as metastasis is often the leading cause of death.
View Article and Find Full Text PDFJMIR Res Protoc
September 2025
University of Nevada, Las Vegas, Las Vegas, NV, United States.
Background: In-hospital cardiac arrest (IHCA) remains a public health conundrum with high morbidity and mortality rates. While early identification of high-risk patients could enable preventive interventions and improve survival, evidence on the effectiveness of current prediction methods remains inconclusive. Limited research exists on patients' prearrest pathophysiological status and predictive and prognostic factors of IHCA, highlighting the need for a comprehensive synthesis of predictive methodologies.
View Article and Find Full Text PDFLangmuir
September 2025
State Key Laboratory of Solid Waste Reuse for Building Materials, Beijing Building Materials Academy of Sciences Research, Beijing 100041, China.
This article is based on the research background of an early performance of shotcrete under low-temperature environments. Silica fume (SF) (silicon powder) and nano-CSH are used to improve the effect of the low-temperature environment on the performance of alkali-free (AF) liquid accelerators and early strength of shotcrete. The results show that the 10% SF and 3% nano-CSH composite admixture significantly enhances AF accelerators' performance at 5 °C, reducing initial and final setting times to 3.
View Article and Find Full Text PDFJCO Glob Oncol
May 2025
Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Purpose: Breast cancer remains a significant public health challenge globally, as well as in India, where it is the most frequently diagnosed cancer in females. Significant disparities in incidence, mortality, and access to health care across India's sociodemographically diverse population highlight the need for increased awareness, policy reform, and research.
Design: This review consolidates data from national cancer registries, global cancer databases, and institutional findings from a tertiary care center to examine the epidemiology, clinical challenges, and management gaps specific to India.