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Article Abstract
Unlabelled: Vitamin D plays a crucial role in bone health and immune function, with serum 25(OH)D levels influenced by genetic, dietary, and metabolic factors.
Background/objectives: This study investigated the impact of rs731236, rs10741657, and rs2282679 polymorphisms, body mass index (BMI), and dietary vitamin D intake on vitamin D status.
Methods: A total of 230 adults were classified into four BMI categories: normal weight (NW), overweight (OW), obesity class I (OB), and obesity class II/III (OP). Participants completed a Food Frequency Questionnaire (FFQ) and a 7-day Food Frequency Diary (FFD). Genotyping was performed using TaqMan assays, and serum 25(OH)D was quantified via spectrophotometry. Statistical analyses included ANOVA and multiple linear regression.
Results: The rs731236 CC genotype, rs10741657 AG/GG, and rs2282679 AC/CC were associated with lower serum vitamin D levels. A higher BMI was significantly correlated with reduced serum 25(OH)D ( < 0.001), with BMI emerging as the strongest predictor of vitamin D status. FFQ-based dietary intake showed a modest positive correlation with 25(OH)D (r = 0.47, < 0.001).
Conclusions: BMI and genetic variants in , , and significantly influence vitamin D metabolism. Personalized interventions addressing genetic predispositions and weight management may improve vitamin D status.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12293828 | PMC |
| http://dx.doi.org/10.3390/diseases13070219 | DOI Listing |
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