Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Introduction: Construction of an animal model of rabbit anterior cruciate ligament (ACL) near isometric reconstruction is a basic condition to study the patterns of graft stress and tendon to bone healing. The impact of alterations in the bone tunnel entrance within the femoral footprint region on graft tension remains uncertain. The objective of this study was to determine the femoral tunnel entrance that provides the closest approximation to near-isometric reconstruction within the femoral ACL footprint.
Materials And Methods: Eighteen Cadaveric rabbit knees were used in this experiment. The semitendinosus autografts were employed for ACL reconstruction. Six knees were reconstructed using the middle position of the femoral footprint area as the entrance (Mi-tunnel), six knees used a position 2 mm anterior to the middle (An-tunnel), and six knees used a position 2 mm posterior to the middle (Po-tunnel). All grafts were pretensioned with 10 N at 150° and 90° flexion and firmly fixed at the tibial end. The change in graft strain was measured under maximum flexion and extension in the rabbit knee joints.
Results: Under a maximum flexion of 150° and 10 N pretension, the graft strain decreased significantly during knee extension in the An-tunnel and Mi-tunnel groups and there was no significant decrease in the Po-tunnel group. There were significant differences in graft strain between the Po-tunnel and An-tunnel during knee extension at 135°-35° ( < 0.05). Under 90° flexion and 10 N pretension, the Po-tunnel group showed a minimal change in graft strain compared to the An-tunnel and Mi-tunnel groups with knee extension and flexion (135°-35°) except at the initial pretension Angle. There was a statistically significant difference in graft tension when the Po-tunnel compared to the An-tunnel ( < 0.05).
Conclusions: The Po-tunnel within the femoral footprint region may be the best choice for ACL near isometric reconstruction in rabbits.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286926 | PMC |
| http://dx.doi.org/10.3389/fsurg.2025.1571180 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Engineering the Microbiome: a Novel Approach to Managing Autoimmune Diseases.
Neuromolecular Med
September 2025
Gilgamesh Ahliya University, Baghdad, Iraq.
Autoimmune diseases occur when the immune system mistakenly attacks the body's own tissues, affecting millions of people and often requiring long-term treatment. Current therapies, such as immunosuppressants and biologics, help manage symptoms but can cause serious side effects. A promising new approach involves engineered microbiota-a method that modifies gut bacteria to influence immune function and potentially ease autoimmune conditions.
View Article and Find Full Text PDFAlthough bacterial vaginosis (BV) affects 30% of women worldwide and is associated with adverse health outcomes, current standard-of-care antibiotics fail in over half of cases and treatments have not improved in over 40 years. Probiotics have been proposed as alternative treatments, but fail to restore an optimal lactobacilli-dominated microbiome in the vast majority of patients. Here, we present findings from a pilot clinical trial demonstrating the successful engraftment of vaginal microbiota transplantations (VMTs) after antibiotic treatment in individuals with recurrent BV.
View Article and Find Full Text PDFBiodistribution and dosimetry of Zirconium-labeled microbiota transplants in the pig gut.
Med Phys
September 2025
Imaging Program, Lawson Research Institute, London, Canada.
Background: The gastrointestinal (GI) microbiota, composed of diverse microbial communities, is essential for physiological processes, including immune modulation. Strains such as Escherichia coli Nissle 1917 support gut health by reducing inflammation and resisting pathogens. Microbial therapies using such strains may restore GI balance and offer alternatives to antibiotics, whose overuse contributes to antibiotic resistance.
View Article and Find Full Text PDFNew Anti-HIV Agents Isolated From Two Euphorbia Species.
Arch Pharm (Weinheim)
September 2025
Department of Organic Cheamistry, University of Belgrade-Faculty of Chemistry, Belgrade, Serbia.
Four previously unreported tigliane diterpenes (1, 2, 4, and 6), along with two known tiglianes (3 and 5), were isolated from the latex of Euphorbia palustris and Euphorbia lucida. The structures of the isolated compounds were elucidated by spectroscopic techniques. Antiviral activity assays for compounds 1‒4 and 6 against HIV-1 and HIV-2 replication were performed on a CD4 T cell line, MT-4 cells.
View Article and Find Full Text PDFAssociation of Left Atrial Dysfunction with Pulmonary Hemodynamics and Cardiovascular Outcomes in Patients with Systemic Sclerosis.
CJC Open
August 2025
Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
Background: Left atrial (LA) reservoir strain (LARS) is emerging as an early marker of cardiac remodelling, providing significant prognostic information. The present study investigated the prevalence of LA dysfunction and its association with pulmonary hemodynamics and cardiovascular (CV) outcomes in systemic sclerosis (SSc) patients.
Methods: We included 52 patients who had SSc without structural cardiac disease.