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Background: Early diagnosis of diabetes mellitus (DM) is the key to controlling it. Dental care settings can offer an opportunity to identify unknown cases of DM. The Indian Diabetes Risk Score (IDRS) is a validated and simple tool designed to predict the type II DM risk in the Indian population.
Objective: To assess the hyperglycaemia among undiagnosed type II DM patients and to compare random blood sugar (RBS) levels between various IDRS risk groups.
Materials And Methods: This research included a sample of patients who visited two dental teaching hospitals for dental treatment between July and September 2024 based on inclusion and exclusion criteria. Diabetes risk was evaluated with IDRS criteria, and capillary RBS was assessed with an Accu-Check glucometer. Chi-square test, Spearman's correlation coefficient, and Mann-Whitney's tests for bivariate analysis, and binomial regression analysis to assess the predictors of hyperglycaemia were used.
Results: A sample of 652 individuals (370 males and 282 females) participated in this cross-sectional study. Around 35% of them were in high risk, 45% in medium risk, and 20% were in low risk categories. RBS levels >200 mg/dL were found in 18.25% of the participants, and among the high-risk patients, 35.65% had RBS levels >200 mg/dL. IDRS high-risk category and above 65 years were the two predictors identified in regression analysis.
Conclusion: Pre-procedural RBS estimation in high and moderate-risk patients is a valuable measure to identify unknown cases and prevent complications of DM. Dental clinics can play a vital role in this.
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http://dx.doi.org/10.4103/jomfp.jomfp_302_24 | DOI Listing |
Clin Exp Med
August 2025
Department of pathology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
This study examined the association between diabetes mellitus and tuberculosis (TB) in a cohort of 200TB-positive patients, stratified by gender, age, treatment regimen, and comorbidities, including diabetes, acute gastroenteritis, and hypertension, compared to TB patients without additional complications. Clinical parameters-Random Blood Sugar (RBS), C-reactive protein (CRP), and Erythrocyte Sedimentation Rate (ESR)-were assessed at baseline and after four months of anti-TB therapy. The results showed no significant changes in mean RBS or CRP levels post-treatment, but a notable reduction in mean ESR was observed.
View Article and Find Full Text PDFDev Neurobiol
October 2025
Department of Child and Adolescent Psychiatry, Ankara University, Ankara, Turkey.
Despite extensive research, the etiological factors contributing to autism spectrum disorder (ASD) remain incompletely understood, with potential influences ranging from genetic predispositions to environmental factors. Sirtuin 1 (SIRT1), an NAD-dependent histone deacetylase involved in mitigating oxidative stress and its association with other neurodevelopmental disorders, explores its function in ASD. This study aimed to elucidate the relationship between SIRT1 and inflammatory cytokines, specifically interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α), in patients with ASD.
View Article and Find Full Text PDFJ Med Entomol
August 2025
Instituto Nacional de Epidemiologia da Amazônia Ocidental-INCT EpiAmO Fiocruz Rondônia, Brasil.
Sugar-based bait stations containing insecticides are used for mosquito control, but few studies compare different bait stations models. This study evaluated mosquito engorgement using sugar bait and attractive sugar bait in 4 bait stations models: ovitrap, artificial plant, resting box, and bottle. Two experiments were conducted: (i) a no-choice test, where mosquitoes were exposed to a single bait stations with 10% sucrose sugar bait or attractive sugar bait, and (ii) a multi-choice test, where all bait stations models were placed in a tent, offering sugar bait and attractive sugar bait at 10% and 70% sucrose concentrations.
View Article and Find Full Text PDFInt J Cardiol Heart Vasc
October 2025
Department of Cardiology, University Heart & Vascular Center Hamburg, Hamburg, Germany.
Unlabelled: Emerging evidence indicates that the circulating biomarker angiopoietin-2 (ANGPT2), bone morphogenetic protein2 10 (BMP10), fibroblast growth factor 23 (FGF23), and insulin-like growth factor-binding protein7 (IGFBP7) reflect distinct pathophysiological vascular and cardiac processes contributing to adverse cardiac remodeling in the context of volume or pressure overload. This study aims to investigate the association between these circulating biomarkers, and the presence of hemodynamically significant pressure or volume overload and adverse clinical outcomes.
Methods: In an observational cohort of outpatient cardiology patients (N = 1506) the relationship between the four emerging biomarkers and pressure/volume overload using multivariable-adjusted regression models was examined.
Life Sci Alliance
November 2025
MOE Key Laboratory of Biosystems Homeostasis and Protection, Institute of Biophysics, College of Life Sciences, Zhejiang University, Hangzhou, China
Gene transcription and translation are fundamental processes that underpin the vitality of living organisms. In bacteria, the classic promoter elements for transcription include the -35 region and the -10 region, whereas the ribosome binding site (RBS) is essential for translation. Our investigation of the upstream sequences of ORFs in has confirmed a -10 region-like motif, which appears as 5'-TANNNT-3' (-10-motif).
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