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Routine electroencephalograms (EEGs) assess brain function, but can be time-consuming, resource-intensive and setting-restrictive. Brain vital signs (BVS) evaluation, derived from EEG-based event-related potentials (ERPs), offers a rapid, standardized evaluation of cognitive function. In this study, 20 outpatients with cognitive complaints underwent both routine EEGs and BVS evaluation. While only 4 participants showed abnormal EEG results, 11 had at least one of the six BVS out-of-range, suggesting increased sensitivity to cognitive impairment. This commentary discusses the feasibility and potential value of standardized BVS evaluation as a simple objective method for cognitive function evaluation.
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http://dx.doi.org/10.1017/cjn.2025.10362 | DOI Listing |
JTCVS Open
August 2025
Department of Surgery, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY.
Objective: Persistent pulmonary air leak happens in a minority of patients with various thoracic pathologies. Spiration (Olympus America Inc.) bronchial valves (BVs) are approved by the Food and Drug Administration under Humanitarian Use Device status to treat persistent air leak after lung resection.
View Article and Find Full Text PDFACS Synth Biol
September 2025
State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.
Large-scale genome simplification represents a fundamental goal in synthetic biology. Baculoviruses, with their biphasic life cycle and inherent genomic plasticity, have emerged as ideal models for synthetic genome engineering. Although modified baculovirus genomes are widely used as expression vectors for robust recombinant protein production, many genomic regions are dispensable for in vitro budded virus (BV) production.
View Article and Find Full Text PDFFront Neurol
August 2025
Department of Neurology, Hospital 450, Durango City, Mexico.
Background: Episodic migraine is a prevalent and disabling neurological disorder with a significant impact on quality of life and productivity. Preventive treatment aims to reduce the frequency, intensity, and disability associated with migraine attacks. However, the comparative efficacy and safety of available preventive strategies remain insufficiently addressed in the literature, especially in low- and middle-income countries.
View Article and Find Full Text PDFPharmaceutics
August 2025
Laboratory of Synthesis and Drug Delivery, Paraiba State University, Rua Horácio Trajano de Oliveira, s/n, Cristo Redentor, João Pessoa 58075-540, PB, Brazil.
Oral mucositis (OM) is a severe inflammatory condition of the oral mucosa that is commonly associated with cancer therapies. Traditional treatments typically have limited efficacy and significant side effects, necessitating alternative approaches. Nanobased drug delivery systems (DDSs) present promising solutions, enhancing therapeutic outcomes while minimizing side effects.
View Article and Find Full Text PDFCurr Issues Mol Biol
July 2025
Department of Plastic Surgery, Colentina Clinical Hospital, 020125 Bucharest, Romania.
Background: Mycosis fungoides (MF), the most prevalent cutaneous T cell lymphoma, features clonal CD4⁺ T cell proliferation within a Th2-dominant microenvironment. Interleukin-4 (IL-4) promotes disease progression while Brentuximab Vedotin (BV), an anti-CD30 antibody-drug conjugate, shows efficacy but faces resistance challenges.
Methods: We conducted a narrative literature review (2010-2024) synthesizing evidence on IL-4 signaling and BV's efficacy in MF to develop a theoretical framework for combination therapy.