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| http://dx.doi.org/10.1053/j.gastro.2025.06.026 | DOI Listing |
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A series of pediatric patients with inflammatory bowel disease switching from intravenous to subcutaneous infliximab maintenance therapy.
Clin Res Hepatol Gastroenterol
September 2025
Pediatric Hepato-Gastroenterology and Nutrition Unit, Hôpital Femme Mère Enfant de Lyon Hôpital Femme Mère Enfant, Hospices Civils de Lyon HCL, Bron, France; Centre International de Recherche en Infectiologie (CIRI), Univ Lyon, Institut national de la santé et de la recherche médical (Inserm),
Objective: Infliximab is approved for pediatric Crohn's disease (CD) and ulcerative colitis (UC), but is limited in children by its intravenous administration. We evaluated the effectiveness and safety of switching from intravenous to subcutaneous infliximab in pediatric patients with CD/UC.
Methods: Multicenter retrospective cohort study, from January to December 2022 in two pediatric centers, that included CD/UC patients in clinical remission and weighing ≥50 kg, treated with maintenance dose IV IFX.
Assessment of Azathioprine-Associated Lymphopenia Incidence Rates in Polish Children with Inflammatory Bowel Disease and Autoimmune Hepatitis: A Retrospective Study.
Children (Basel)
August 2025
Department of Paediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Background And Objective: Thiopurines (azathioprine (AZA) and 6-mercaptopurine (6-MP)), used to maintain remission in inflammatory bowel diseases (Crohn's disease (CD), ulcerative colitis (CU)) and autoimmune hepatitis (AIH), are responsible for a number of adverse effects. One is leukopenia, mainly due to neutropenia and less known lymphopenia. This study aimed to assess the incidence rate of lymphopenia in pediatric patients with CD, CU, and AIH treated with azathioprine (AZA) and to evaluate the impact of lymphopenia on the occurrence of opportunistic infections and its relationship with disease activity, treatment, and nutritional status.
View Article and Find Full Text PDFPlasma interleukin-22 concentration and disease activity in inflammatory bowel disease.
Sci Rep
August 2025
Faculty of Medicine, Imperial College London, London, UK.
The relationship between interleukin-22 and clinical characteristics of patients with inflammatory bowel disease is uncertain. We sought to determine whether plasma interleukin-22 concentrations are associated with disease activity in a large population of patients with inflammatory bowel disease. This was an observational study of patients with Crohn's disease or ulcerative colitis in the Study of a Prospective Adult Research Cohort with IBD (SPARC IBD) from the IBD Plexus registry of the Crohn's & Colitis Foundation in the United States.
View Article and Find Full Text PDFMesenteric fat proliferation on magnetic resonance enterography is a predictor of long-term disease complications in crohn's disease.
BMC Gastroenterol
August 2025
Inflammatory Bowel Diseases Service, Gastroenterology Institute, Rambam Health Care Campus, Haaliya 2 Str., Haifa, Israel.
Background: Fibrofatty proliferation of mesenteric fat is a common finding on magnetic resonance enterography (MRE) in Crohn's disease (CD) patients. Mesenteric fat may play a role in inflammation, fibrosis, and stricture formation, but its prognostic value in predicting complications remains unclear.
Objectives: To assess the association between mesenteric fat proliferation on MRE and the risk of hospital admissions and bowel surgery in CD patients.
Randomized controlled trial of a natural whole food diet versus habitual diet for Crohn's disease: Is diet quality the key?
Clin Nutr ESPEN
August 2025
Center for Human Nutrition, Division of Clinical Nutrition, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Background & Aims: Diets can help induce remission in patients with Crohn's disease (CD). However, given inconsistent recommendations across purportedly beneficial anti-inflammatory diets and prior studies highlighting benefits of plant-based diet patterns, we hypothesized that the benefit of diet therapy stems from the overall "healthfulness" of diet patterns.
Methods: In a randomized controlled trial, adults with mild-to-moderate CD were assigned to receive guidance on a natural whole food diet that comprised principles of a healthful diet versus continuation of one's habitual diet.