Publications by authors named "Thomas Loppinet"
A series of pediatric patients with inflammatory bowel disease switching from intravenous to subcutaneous infliximab maintenance therapy.
Clin Res Hepatol Gastroenterol
September 2025
Objective: Infliximab is approved for pediatric Crohn's disease (CD) and ulcerative colitis (UC), but is limited in children by its intravenous administration. We evaluated the effectiveness and safety of switching from intravenous to subcutaneous infliximab in pediatric patients with CD/UC.
Methods: Multicenter retrospective cohort study, from January to December 2022 in two pediatric centers, that included CD/UC patients in clinical remission and weighing ≥50 kg, treated with maintenance dose IV IFX.
Background: Antibiotic therapy for neonatal Staphylococcus aureus bacteremia (NSAB) is recommended for at least 14 days. However, this recommendation is based on very limited data. This study aimed to compare NSAB relapses between patients treated for less than 14 days versus 14 days or more in neonatal intensive care units.
View Article and Find Full Text PDFBackground: Although initial clinical presentation of hyperekplexia/startle disease is well known, data regarding long-term clinical outcomes is lacking.
Objectives: We provide a long-term evaluation from clinical and pharmacological perspectives, focusing on neurodevelopmental trajectory.
Methods: Twenty-eight patients from nine French hospitals were included based on clinical diagnosis criteria.
Article Synopsis
- Diabetic ketoacidosis (DKA) is a serious condition that can occur in children with type 1 diabetes, and stopping intravenous insulin can lead to high blood sugar again.
- This study evaluated two treatment protocols in children recovering from DKA: one where insulin was given after stopping IV infusion, and another where long-acting insulin was given before stopping the IV.
- Results showed that the new protocol with early long-acting insulin significantly reduced the risk of ketosis rebound compared to the old protocol.
Article Synopsis
- * Conducted retrospectively, the research included infants born before 32 weeks of gestation from 2012 to 2021, analyzing various support methods used and outcomes of early or late weaning failure.
- * Results showed that 43% of infants were weaned before 6 months of age, with factors like the duration of invasive ventilation and postnatal steroid treatment linked to later weaning failures.
The DAV132 colon-targeted adsorbent does not interfere with plasma concentrations of antibiotics but prevents antibiotic-related dysbiosis: a randomized phase I trial in healthy volunteers.
Nat Commun
September 2024
Article Synopsis
- A study found that antibiotics can harm the good bacteria in our bodies and make cancer treatments less effective, particularly a type of treatment called immune checkpoint inhibitors (ICI).
- Researchers tested a new treatment called DAV132 on healthy volunteers to see if it could help fix the issues caused by antibiotics, and it turned out to be safe and did not change antibiotic levels too much.
- In mice tests, DAV132 helped keep the good bacteria safe and improved the effectiveness of cancer treatments compared to those given antibiotics alone. This means DAV132 might be a good way to protect the bacteria and help cancer patients who take antibiotics.
Haemodialysis versus peritoneal dialysis in children: an eco-audit.
Nephrol Dial Transplant
October 2024
Knowledge and beliefs of endocrine disruptors in pediatrics: all hands on deck!
Front Public Health
July 2024
Article Synopsis
- Endocrine disruptors (ED) are widespread pollutants linked to chronic diseases, particularly affecting vulnerable groups like infants and children, highlighting a need for better information for parents.
- A study conducted at Lyon Mother and Child Hospital surveyed 746 individuals, including 444 pediatric healthcare professionals and 302 parents, revealing that while most had heard of ED, only 10% of parents and 5% of professionals felt well-informed about them.
- The findings showed that professionals generally had better knowledge than parents (73% vs. 60%), but only a small percentage had engaged with scientific literature or training on EDs, indicating the necessity for specific educational initiatives.
Article Synopsis
- * The study found that women were generally older and more likely to have hypertension, but the overall infarct size and left ventricular ejection fraction were similar between genders.
- * Elevated left ventricular filling pressure (LVFP) was more common in women at both initial hospitalization and one year later, and it independently predicted rehospitalization for HF alongside age and hypertension.
Introduction: Water distribution systems in hotels have been related to outbreaks caused by spp. Certain measures, including disinfection by chlorination, maintaining increased temperatures are usually undertaken to prevent outbreaks. However, these preventive strategies are not always effective, since there are several factors (e.
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