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http://dx.doi.org/10.1016/j.cmi.2025.07.011 | DOI Listing |
J Control Release
September 2025
Department of Bioengineering, Rice University, Houston, TX, USA. Electronic address:
The development of continuous-release devices or injectables for the long-term delivery of biologics is of great interest, especially monoclonal antibodies (mAbs) that require frequent, high-dose injections. Preclinical testing of these technologies in murine models is necessary for clinical translation; however, xenogeneic responses to the mAb and foreign body responses to the implants or injectables can confound results. Immune system knockout (KO) models that affect immune cells are often used in these experiments, but the effects of KO models on mAb pharmacokinetics (PK) are not well characterized.
View Article and Find Full Text PDFPest Manag Sci
September 2025
School of Life Sciences, Genetic Engineering Research Center, Chongqing University, Chongqing, China.
Background: Entomopathogenic fungi show great potential as biological control agents for managing insect pests. However, host defenses have limited the effectiveness of these fungi in practice. Utilizing genetic engineering-based technology could be a promising strategy to enhance the killing efficiency of these fungi against insect pests.
View Article and Find Full Text PDFEnviron Sci Technol
September 2025
Key Laboratory for Environment and Disaster Monitoring and Evaluation of Hubei, Jianghan Plain-Honghu Lake Station for Wetland Ecosystem Research, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430077, China.
Despite the widely acknowledged importance of small water bodies (SWBs), their large-scale capacity for nitrogen (N) removal in agricultural landscapes remains poorly understood. This study assessed the N removal efficiency and potential of 1.75 million SWBs (<0.
View Article and Find Full Text PDFVaccines (Basel)
July 2025
Laboratory of Adjuvant and Antigen Research, US Military HIV Research Program, Center for Military Infectious Diseases Research, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
: Opioid use disorder (OUD) remains a severe health problem globally, resulting in substantial social and economic challenges. While existing medications for managing OUD are proven to be effective, they also present certain challenges. A vaccine offers a promising therapeutic strategy to combat OUD and potentially reduce the risk of overdose death.
View Article and Find Full Text PDFBMC Womens Health
August 2025
Exos, 2629 E Rose Garden Lane, Phoenix, Arizona, 85050, USA.
Background: Hormonal-related symptoms experienced during natural or contraceptive-driven menstrual cycles have implications on work-related productivity; however, employer-sponsored menstrual health resources are widely unavailable. Actionable research-based evidence is needed to develop menstrual health programs that proactively help working females mitigate their hormonal-related symptoms and optimize their hormone profiles and work-related performance. This study sought to evaluate the prevalence and severity of hormonal-related symptoms and assess the directional impact of hormonal-related symptoms on work-related productivity across cyclical hormone phases.
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