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Background: This global cross-sectional study analyzed data from 266 "countries" and territories to evaluate the relationship between the nursing and midwifery workforce size (NMWS) and maternal mortality ratios (MMR). Drawing from five major United Nations and World Bank databases, the study offers robust and generalizable insights across diverse health systems and economic settings.
Methods: The study examined the association between the NMWS and MMR using scatterplots, bivariate and partial Pearson correlation coefficients, and multiple and stepwise linear regression models. Key confounding variables, including economic affluence measured by the gross domestic product (GDP) per capita adjusted for purchasing power parity, total fertility rate, and urbanization, were included to isolate the independent contribution of the NMWS to maternal health outcomes at the global and regional levels.
Results: The NMWS accounted for 49.13 percent of the global variation in maternal mortality ratios, which indicates a strong inverse relationship. After adjusting for economic and demographic variables, the NMWS remained a significant independent predictor and explained 11.09 percent of the variance. A stepwise regression identified the NMWS as the second most influential predictor of maternal mortality after economic affluence and the fertility rate. The association was strongest in low- and middle-income countries, where workforce shortages and the maternal mortality rates are highest.
Conclusions: This study identifies the NMWS as a critical and measurable factor in reducing maternal mortality worldwide. This study's findings provide compelling evidence for a strategic investment in the nursing and midwifery workforce. Expanding this workforce is essential to improve the maternal health outcomes, especially in countries with limited resources, and should be prioritized in global maternal health and workforce planning strategies.
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http://dx.doi.org/10.3934/publichealth.2025031 | DOI Listing |
Eur J Prev Cardiol
September 2025
Department of Cardiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Background And Aims: Data on cardiovascular outcomes and aortic growth in pregnant women with Turner syndrome is limited. We examine the cardiovascular and pregnancy outcomes in these women and analyze aortic growth throughout pregnancy.
Methods: The ROPAC III is a global, prospective, observational registry that enrolled pregnancies of women pre-pregnancy known with Turner syndrome from 2018 to 2023.
Pediatr Transplant
November 2025
D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil.
Background: Fontan-associated liver disease can progress to advanced fibrosis, raising the potential need for combined heart-liver transplantation (CHLT) in selected patients. However, the benefits of CHLT over isolated orthotopic heart transplantation (HT), particularly in terms of mortality, remain uncertain. In this systematic review, we compared mortality outcomes following CHLT versus HT in patients with Fontan circulation, with the aim of supporting clinical decision-making.
View Article and Find Full Text PDFCurr Pharm Des
September 2025
Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan, 45142, Saudi Arabia.
Introduction: Cervical cancer (CC) is among the most prevalent cancers affecting women globally, with a substantial number of deaths reported annually. Despite advancements in treatment, the persistently high mortality rate underscores the urgent need for novel and effective therapeutic strategies.
Methods: This study screened a library of 240 flavonoids against maternal embryonic leucine zipper kinase (MELK) and LYN using molecular docking methods to achieve precise calculations.
Trends Cardiovasc Med
September 2025
Department of Cardiology, NYU Langone Health and NYU School of Medicine, New York, NY.
Cardio-obstetrics is a growing sub-specialty focused on the prevention, diagnosis, and management of high-risk pregnancies in women with cardiac disease, a condition affecting 1-4% of pregnancies and a leading cause of indirect maternal mortality in developed countries. The prevalence of maternal cardiac disease is rising due to factors such as increasing maternal age, obesity, comorbidities, and improved survival of individuals with congenital heart disease. Artificial intelligence (AI) is increasingly used in cardiology to enhance early diagnosis, risk stratification, and treatment planning, offering promising tools to support the diagnostic and therapeutic complexities of maternal cardiac disease.
View Article and Find Full Text PDFInt J Obstet Anesth
September 2025
Westmead Hospital Department of Anaesthesia and Perioperative Medicine, Westmead, Australia.
Background: Maternal cardiovascular disease (CVD) is a leading cause of maternal mortality. Data on anaesthetic management in patients with CVD is limited.
Methods: This ten-year retrospective cohort study of 508 pregnancies in women with CVD, stratified by modified World Health Organization (mWHO) risk category, compared lowrisk (mWHO I-II) (n = 323) and high-risk (mWHO II to III-IV) (n = 185) groups to a control obstetric population (n = 55,153).