Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Progesterone receptors are involved in the regulation of tumor cell proliferation and therefore can be considered as a target of antitumor drugs. However, the question of the concordance of quantitative indicators of the protein and mRNA produced as a result of the expression of a single gene remains open. In this study, the concordance of the expression of the progesterone receptor protein and mRNA was evaluated using real-time PCR and flow cytometry, respectively, in 10 tumor cell lines (T47D, A375, PANC-1, SNU-1, HT-29, OVCAR-3, BXPC-3, HCC1954, A549, MCF-7). The expression of the progesterone receptor protein was detected in all studied cell lines; the expression of progesterone receptor mRNA was detected only in the T47D, which shows the discordance of these indicators and queries the relevance of measuring the expression of tumor marker mRNA when selecting the targeted anti-tumor drugs for the treatment of oncological diseases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-025-06448-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Progesterone-induced activation of progesterone receptor alleviates alveolar bone resorption and inflammatory response in periodontitis.
Clin Oral Investig
September 2025
Department of Stomatology, Shengli Oilfield Central Hospital, No. 31, Jinan Road, Dongying, 257034, China.
Objective: Progesterone (PG) and its target, progesterone receptor (PGR), are important regulators in inflammatory diseases. This study aimed to investigate the specific role of PG in periodontitis and to elucidate the underlying mechanisms involving PGR.
Methods: Women with periodontitis, including 250 with PG deficiency, 250 with PG supplementation, and 245 controls (normal PG) were enrolled.
Screening for anti-dysmenorrhea components of Wenjing Decoction: spectral-effect relationship analysis, and efficacy equivalence validation.
J Ethnopharmacol
September 2025
The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, China; Key Laboratory of Research and Transformation on Prevention and Treatment of Major Diseases in Internal Medicine of Traditional Chinese Medicine, Ministry of Education, Changsha 410007, China. Electronic address: mic
Ethnopharmacological Relevance: Primary dysmenorrhea (PD) is common and has a major impact on women's daily activities and quality of life. Wenjing Decoction (WD), a classic Chinese medicine formula, has been widely used for thousands of years in China to treat PD. However, the key pharmacodynamic substances in WD responsible for its anti-dysmenorrhea efficacy are still unclear.
View Article and Find Full Text PDFMedical treatment of fibroids: FIGO best practice guidance.
Int J Gynaecol Obstet
September 2025
Department of Gynecology and Obstetrics, Justus Liebig University Giessen, Giessen, Germany.
Even though uterine fibroids are a widespread condition, the range of approved medical treatment options remains limited. In fact, only a few drugs are officially approved for the therapy of fibroids. In both the USA and the European Medicines Agency region, selected gonadotropin-releasing hormone (GnRH) antagonists have been approved for this indication.
View Article and Find Full Text PDFApplicability of Oncotype DX Testing in a Diverse Breast Cancer Population in Hawaii.
Breast J
September 2025
University of Hawai'i Cancer Center, Honolulu, Hawaii, USA.
The Oncotype DX test is standardly used for patients with early-stage, hormone-receptor-positive, HER2-negative breast cancers to determine the benefit from chemotherapy and the likelihood of distant recurrence. The relationship between Oncotype DX recurrence scores and race/ethnicity is still being studied. This retrospective study aims to evaluate the relationship between Oncotype DX recurrence scores, race/ethnicity, and clinicopathological factors and to support the applicability of the Oncotype DX test for a diverse breast cancer population of Hawaii.
View Article and Find Full Text PDFA Case Report of Synchronous Multicentric Breast Carcinoma With Biologically Discordant Phenotypes: Luminal A and Triple-Negative Subtypes.
Cureus
August 2025
Medicine, Academy of Silesia, Katowice, POL.
We present the case of a 45-year-old Caucasian woman diagnosed with synchronous bicentric breast cancer of differing molecular phenotypes in the same breast. The first tumor, an invasive ductal carcinoma (G1), was estrogen and progesterone receptor-positive and HER2-negative, with a low proliferative index (Ki67 10%). A second lesion, located in a different quadrant and appearing within weeks after biopsy, exhibited a triple-negative phenotype and a higher proliferative index (Ki67 30%).
View Article and Find Full Text PDF