Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
We studied the effect of increasing and decreasing the deuterium level on the mitochondrial membrane potential (MMP), Ca homeostasis, and neuronal death in the rat cerebellar neurons in vitro. It was found that decreasing deuterium concentration to 100 and 50 ppm was accompanied by gradual depression of MMP and a decrease in the level of cytosolic Ca compared to the baseline values at deuterium concentration 150 ppm. Increasing deuterium concentration to 300 and 750 ppm was associated with an increase in MMP and Ca levels. A decrease in deuterium concentration to 100 ppm and its increase to 300 and 750 ppm reduced neuronal death after glucose deprivation. A decrease in deuterium concentration to 50 ppm produced no protective effect. Possible mechanisms for these effects are proposed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-025-06424-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Feasibility of High-Resolution Deuterium Metabolic Imaging of the Human Kidney Using Concentric Ring Trajectory Sampling at 7T.
NMR Biomed
October 2025
High-Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.
The human kidneys play a pivotal role in regulating blood pressure, water, and salt homeostasis, but assessment of renal function typically requires invasive methods. Deuterium metabolic imaging (DMI) is a novel, noninvasive technique for mapping tissue-specific uptake and metabolism of deuterium-labeled tracers. This study evaluates the feasibility of renal DMI at 7-Tesla (7T) to track deuterium-labeled tracers with high spatial and temporal resolution, aiming to establish a foundation for potential clinical applications in the noninvasive investigation of renal physiology and pathophysiology.
View Article and Find Full Text PDFElectroreductive Denitrogenation of Tetrazolo[1,5-]quinoxalin-4(5)-ones to 3-Aminoquinoxalin-2(1)-ones.
J Org Chem
September 2025
Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Jadavpur, Kolkata 700 032, India.
The denitrogenation of tetrazoles is typically performed using transition-metal catalysts at high temperatures due to the inherent stability of the tetrazole group. In this work, we present, for the first time, an electrochemical method for denitrogenating tetrazoles at room temperature. This method employs a sacrificial zinc anode and a platinum cathode in a solvent mixture of acetonitrile and water under a constant current in an undivided cell.
View Article and Find Full Text PDFProbing Intracellular Yeast Metabolism With Deuterium Magnetic Resonance Spectroscopy.
NMR Biomed
October 2025
Section Biomedical Imaging, Molecular Imaging North Competence Center, Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Kiel University, Kiel, Germany.
Metabolomics provides snapshots of states of metabolites under specific conditions, with nuclear magnetic resonance (NMR) being one of the few noninvasive techniques. However, when applied to intact cells (e.g.
View Article and Find Full Text PDFComparison of Low-Rank Denoising Methods for Dynamic Deuterium MRSI at 7 T.
NMR Biomed
October 2025
High Field MR Center, Department for Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.
Dynamic deuterium (H)-MRSI enables mapping of metabolic fluxes in vivo, but its sensitivity is hampered by the low H gyromagnetic ratio and H-labelled metabolite concentrations. Low-rank denoising can enhance MRSI sensitivity by separating signal from noise. Several methods have been proposed, but the optimal approach for dynamic H-MRSI remains unclear.
View Article and Find Full Text PDF