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Flank bulge (FB) is a rare postoperative complication, most commonly following surgery with retroperitoneal access through flank incision. It is characterized by relaxation of anterolateral wall muscles with abnormal protrusion of the abdominal wall. The assumed pathomechanism is iatrogenic injury of the intercostal nerves T11/T12. During congenital diaphragmatic hernia (CDH) repair, dissection and sutures are necessary at this thoracic level. We aimed to assess the risk of FB in a consecutive series of patients after CDH repair.We retrospectively analyzed charts of all patients after CDH repair (2007-2024) with a follow-up of ≥3 months. FB was diagnosed during clinical follow-up examinations and defined as protrusion of abdominal wall with no sonographic evidence for hernia. Surgical variables and their association with FB were evaluated. For statistical analysis, Pearson's and Student's t-test were used. Multivariate logistic regression was performed to identify independent risk factors associated with FB development after CDH repair.Among 67 infants undergoing CDH repair with follow-up, 76% underwent open surgery and 48% required patch repair. Postoperative FB occurred in 11% of patients, exclusively following open repair with patch, and was significantly associated with rib sutures and higher birth weight. One-third of FB cases resolved spontaneously, while the remainder persisted, though without functional impairment.FB may be an underestimated complication after open CDH repair. Routine assessment of abdominal wall tone is recommended during follow-up after CDH repair. Larger studies are needed to clarify the clinical impact, patient-perceived level of disability, and long-term sequelae.
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http://dx.doi.org/10.1055/a-2649-0722 | DOI Listing |
J Surg Case Rep
September 2025
Pediatric Surgery Department A, Children Hospital Bechir Hamza, 167, 9th of April Boulevard, Tunis, Tunisia.
We report a case of concurrent congenital diaphragmatic hernia (CDH) and Hirschsprung's disease (HD) in a neonate without syndromic features, representing one of fewer documented cases worldwide. The patient presented with classic CDH symptoms but developed persistent bowel obstruction post-repair, leading to delayed HD diagnosis 4 weeks later. This case highlights the diagnostic challenges in differentiating postoperative ileus from underlying HD in CDH patients.
View Article and Find Full Text PDFIntroduction: Congenital diaphragmatic hernia (CDH) can result in intrathoracic displacement of the kidney, presenting anatomical challenges for robot-assisted radical nephrectomy (RARN). Reports of RARN in such cases are scarce.
Case Presentation: A 56-year-old man with a history of right-sided CDH repair was referred for evaluation of an incidentally discovered right renal mass.
Genetics
September 2025
The University of Texas at Arlington, 701 South Nedderman Drive, Arlington, TX 76019, USA.
Physical interactions between cells can profoundly impact cell fate. A vital cell fate for normal development and homeostasis is programmed cell death. Cells fated to die must be efficiently cleared via phagocytosis, with defects associated with a variety of diseases.
View Article and Find Full Text PDFSudan J Paediatr
January 2025
Department of Pediatric Surgery, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Congenital diaphragmatic hernia (CDH) is a severe developmental anomaly with variable clinical outcomes, influenced by factors such as liver herniation, pulmonary hypertension and associated anomalies. While familial clustering of CDH has been described, its occurrence in monozygotic twins remains rare. We report the case of premature monozygotic female twins diagnosed prenatally with left-sided CDH, delivered at 30 weeks and 1 day of gestation due to maternal haemolysis, elevated liver enzyme levels and low platelet levels syndrome.
View Article and Find Full Text PDFActa Paediatr
September 2025
Institute of Systems Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Aims: Congenital diaphragmatic hernia (CDH) is associated with lung hypoplasia, pulmonary hypertension and high mortality. Three decades experience from a UK centre is reported.
Methods: Medical records of CDH newborns between February 1990 and November 2021 and attending a multidisciplinary clinic were examined.