Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/pbc.31908 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biomimetic nanocarriers for the therapy and management of intestinal inflammations.
Int J Pharm X
December 2025
Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Sector-125, Noida 201313, India.
Intestinal inflammation particularly inflammatory bowel disease poses significant clinical challenges due to its chronic nature, limited treatment efficacy and adverse effects of conventional therapies like corticosteroids and biologics. Biomimetic nanocarriers have emerged as a transformative strategy to overcome these limitations by leveraging natural cell membranes for targeted drug delivery. This review critically examines the application of biomimetic nanocarriers as precision therapeutics for intestinal inflammation.
View Article and Find Full Text PDFRapid development of Philadelphia chromosome-negative AML in a CML patient with sustained major molecular response to tyrosine kinase inhibitor therapy.
Leuk Res Rep
August 2025
Department of Hematology, The Second Hospital & Clinical Medical School, Lanzhou University, No. 82, Cuyingmen, Lanzhou, Gansu Province 730030, China.
The use of TKIs has significantly improved the prognosis of CML. However, a small subset of patients still experience poor outcomes. We present a rare case of Ph-AML following a diagnosis of CML.
View Article and Find Full Text PDFAltered Dynamic Network Stability in Remitted Late Life Depression Associated with Depression Recurrence.
Biol Psychiatry Cogn Neurosci Neuroimaging
September 2025
University of Illinois at Chicago, Department of Psychiatry. Electronic address:
Background: Late-life depression (LLD) is associated with negative outcomes including high rates of recurrence and cognitive decline. However, the neurobiological changes influencing such outcomes in LLD are not well understood. Disequilibrium in large-scale brain networks may contribute to LLD-related cognitive decline.
View Article and Find Full Text PDFDual-function fab-scFv fusion antibody ameliorates ulcerative colitis by targeting hFcRn-mediated colonic enrichment and TNF-α neutralization.
Int J Biol Macromol
September 2025
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address:
Ulcerative colitis (UC), a chronic inflammatory bowel disease (IBD), is characterized by disruption of intestinal barrier function and complex inflammatory manifestations locally and systemically. Although anti-tumor necrosis factor-α (TNF-α) agents such as Infliximab (IFX) are effective in treating IBD, their intestinal tissue concentration has been regarded as determinant of therapeutic efficacy while was restrained by the large molecular weight. Considering the enhanced expression of human neonatal Fc receptor (hFcRn) in UC tissues, we attempted to deliver the therapeutic entity of IFX into UC tissues by developing a novel dual-acting IFX Fab-F8 (IFX-F8) fusion protein for UC treatment.
View Article and Find Full Text PDFCLIPPERS syndrome following papillary thyroid carcinoma.
BMJ Case Rep
September 2025
Department of Clinical Neurology, Tbilisi State Medical University, Tbilisi, Georgia.
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a brainstem syndrome marked by punctate 'pepper-and-salt' enhancement on MRI and corticosteroid responsiveness. Evidence suggests that CLIPPERS may represent a cancer-related immune reaction, occurring before tumour detection, in association with active malignancy or after treatment. We report the first case associated with papillary thyroid carcinoma (PTC).
View Article and Find Full Text PDF