Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: The modified Fisher score is commonly used after aneurysmal subarachnoid hemorrhage (aSAH) to estimate hemorrhage burden and support early prognostication, although its accuracy in predicting cognitive outcomes remains limited. This study compares the predictive value of the subjective asessment of aSAH volume through the modified Fisher score with an objetive volumetric quantification in prognosticating cognitive outcomes.
Methods: This retrospective observational study included patients with aSAH between 2009 and 2024 and good functional recovery (modified Rankin score ≤ 2) at least 6 months after aSAH. Cognitive outcomes were assessed using Montreal Cognitive Assessment scores normalized to population data, with poor outcomes defined as Montreal Cognitive Assessment scores < 25th percentile for normative data. A semiautomated method was used to quantify hemorrhage volume from presentation on computed tomography scans. Logistic regression, receiver operating characteristic curves, and mediation analyses were conducted to evaluate the potential relationship between aSAH volume, clinical variables, and cognitive outcomes.
Results: A total of 142 patients with aSAH were included in the study, with 30% of patients (43/142) experiencing poor cognitive outcomes. The objective quantification of hemorrhage volume demonstrated a superior predictive performance compared with the modified Fisher score in determining poor cognitive outcomes (area under the curve 0.75 vs. 0.66, p = 0.037). An aSAH volume cutoff of 24 mL yielded a sensitivity of 72% and a specificity of 60% in predicting poor cognitive outcomes. Mediation analysis revealed partial mediation by vasospasm in the relationship between hemorrhage volume and poor cognitive outcomes.
Conclusions: There is a high rate of cognitive impairment among survivors with aSAH with good functional recovery. Volume quantification outperformed the modified Fisher score in predicting cognitive outcomes after aSAH. aSAH volumes more than 24 mL are linked to worse outcomes, with vasospasm contributing to this association.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12028-025-02326-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Development of the SCI-BodyMap-Measuring Mental Body Representations in Adults With Spinal Cord Injury: Protocol for Item Generation, Reliability, and Validity Testing.
JMIR Res Protoc
September 2025
Division of Physical Therapy and Rehabilitation Science, Department of Family Medicine and Community Health, Medical School, University of Minnesota-Twin Cities, Minneapolis, MN, United States.
Background: Approximately 69% of Americans with spinal cord injury (SCI) have neuropathic pain. Research suggests that impairments in mental body representations (MBRs; ie, representations of the body in the brain) likely contribute to neuropathic pain. Clinical trials in adults with SCI, focused on restoring MBR, led to improvements in sensation and movement as well as neuropathic pain relief.
View Article and Find Full Text PDFEffectiveness, Usability, and Acceptability of ChatGPT With Retrieval-Augmented Generation (SIV-ChatGPT) in Increasing Seasonal Influenza Vaccination Uptake Among Older Adults: Quasi-Experimental Study.
J Med Internet Res
September 2025
School of Governance and Policy Science, The Chinese University of Hong Kong, Hong Kong, China (Hong Kong).
Background: Older adults are more vulnerable to severe consequences caused by seasonal influenza. Although seasonal influenza vaccination (SIV) is effective and free vaccines are available, the SIV uptake rate remained inadequate among people aged 65 years or older in Hong Kong, China. There was a lack of studies evaluating ChatGPT in promoting vaccination uptake among older adults.
View Article and Find Full Text PDFAssociation Between In-Hospital Applications for Long-Term Care Services and Hospital Length of Stay Among Older Adults: Ecological Cross-Sectional Study.
JMIR Form Res
September 2025
Department of Health Economics, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Research Institute, Obu, Japan.
Background: Delayed discharge among older patients presents a major challenge for the efficiency of health service delivery. Prolonged hospitalizations limit bed turnover, increase costs, and reduce the availability of hospital resources. In Japan, older adults must undergo a formal care needs certification process to access public long-term care (LTC) services.
View Article and Find Full Text PDFPersonalized Interactive Music Systems for Physical Activity and Exercise: Exploratory Systematic Review and Meta-Analysis.
JMIR Hum Factors
September 2025
Department of Music, Arts and Culture Studies, Centre of Excellence in Music, Mind, Body and Brain, University of Jyväskylä, Seminaarinkatu 15, Jyväskylän yliopisto, Jyväskylä, 40014, Finland, 358 6643034.
Background: Personalized Interactive Music Systems (PIMSs) are emerging as promising devices for enhancing physical activity and exercise outcomes. By leveraging real-time data and adaptive technologies, PIMSs align musical features, such as tempo and genre, with users' physical activity patterns, including frequency and intensity, enhancing their overall experience.
Objective: This exploratory systematic review and meta-analysis evaluates the effectiveness of PIMSs across physical, psychophysical, and affective domains.
Chronic Health Conditions and Academic Achievement: A Childhood Cancer Survivor Study Report.
JCO Oncol Pract
September 2025
Princess Margaret Cancer Centre, Toronto, Canada.
Purpose: To examine associations between special education, chronic health conditions (CHCs), and college graduation in survivors of childhood cancer and their siblings.
Methods: Childhood Cancer Survivor Study participants included 23,082 5-year survivors (53.7% male; median [IQR] age at diagnosis, 6 [3-13] years; age at evaluation, 31.