Stentplasty for treating symptomatic intracranial atherosclerotic disease following failure of medical therapy.

Purpose: Endovascular treatment of intracranial atherosclerotic disease (ICAD) remains challenging due to procedural risks and stroke recurrence. Previous trials have favored aggressive medical therapy. In patients refractory to medical therapy, 'stentplasty' using expandable and retrievable devices may provide a safer alternative to balloon angioplasty by allowing controlled submaximal vessel dilation without flow arrest.

Inter-rater reliability of atherosclerotic plaque enhancement on 7 T vessel wall MRI: Comparison with quantitative analysis.

ObjectiveIntracranial plaque enhancement (IPE) is a potential biomarker of plaque vulnerability but lacks a standardized definition. While subjective assessment may be prone to observer variability, a voxel-based quantification method can detect subtle signal intensity (SI) changes. This study aimed to compare the inter-rater reliability of subjective IPE evaluation with that of a voxel-based quantification method.

Correlations between hemodynamics and radiomic features in thrombosed intracranial aneurysms.

Purpose: Evaluating intracranial aneurysm (IA) rupture risk is essential for guiding management. Although intrasaccular thrombosis (IST) is less common, it can contribute to aneurysm growth, mass effect, and rupture. Aneurysm wall enhancement (AWE) on high-resolution MRI (HR-MRI) offers valuable insight into IST and IA progression.

Volume of Aneurysmal Subarachnoid Hemorrhage and Cognitive Outcomes.

Background: The modified Fisher score is commonly used after aneurysmal subarachnoid hemorrhage (aSAH) to estimate hemorrhage burden and support early prognostication, although its accuracy in predicting cognitive outcomes remains limited. This study compares the predictive value of the subjective asessment of aSAH volume through the modified Fisher score with an objetive volumetric quantification in prognosticating cognitive outcomes.

Methods: This retrospective observational study included patients with aSAH between 2009 and 2024 and good functional recovery (modified Rankin score ≤ 2) at least 6 months after aSAH.

Impact of Clinical Variables and Aneurysm Morphology on Hemorrhage Volume and Clinical Outcomes.

Background And Objectives: It is unknown what determines the volume of aneurysmal subarachnoid hemorrhage (aSAH). We aimed to investigate the features associated to the burden of subarachnoid hemorrhage after aneurysm rupture and its impact on clinical outcomes.

Methods: Patients admitted with aSAH between 2009 and 2022 were included.

Hemodynamic analysis of thrombosed intracranial aneurysms: a comparative correlation study.

A small fraction of intracranial aneurysms (IA) contains intrasaccular thrombosis (IST). This study explores the hemodynamic causes of IST formation in IAs. We performed computational hemodynamic analysis in 26 IAs: 13 thrombosed and 13 non-thrombosed.

The effect of aspirin on aneurysm wall enhancement: A study in rabbits and humans.

ObjectiveAneurysm wall enhancement (AWE) is a potential biomarker of inflammation within the aneurysm wall that has been correlated with a higher risk of rupture. Aspirin (ASA) may decrease AWE due to its anti-inflammatory properties. We aimed to assess the effect of ASA on AWE in an animal model and a cohort of patients with unruptured intracranial aneurysms (UIAs).

Predictive models for assessing the risk of brain aneurysm rupture.

Objective: Increased contrast enhancement of the aneurysm wall may indicate aneurysm instability. The authors tested different predictive models of aneurysm instability on a cohort of patients imaged with high-resolution magnetic resonance imaging (HR-MRI).

Methods: Patients with intracranial aneurysms were prospectively scanned with HR-MRI.

Super-large bore catheter in the treatment of large vessel occlusions: initial multicenter experience.

Purpose: Large bore catheters are increasingly used in mechanical thrombectomy (MT) for large vessel occlusions (LVOs).

Objective: To evaluate the efficacy and safety of the super-large bore Cereglide 0.092" (C-92) catheter, featuring the largest inner diameter available.

Multicenter study of association between socioeconomic status and treatment of ruptured cerebral aneurysms compared to unruptured cerebral aneurysms: insights from 4,517 patients using the area deprivation index.

Background: Socioeconomic status influences health outcomes, including cerebrovascular diseases. Patients from socioeconomically deprived areas may present with more severe conditions due to delayed access to care. This study evaluates the association between neighborhood-level deprivation, measured by the Area Deprivation Index (ADI), and the treatment of ruptured intracranial aneurysms (RIAs) compared with unruptured intracranial aneurysms (UIAs) across multiple centers.

Comprehensive morphomechanical and wall enhancement analysis of intracranial aneurysms.

Introduction: Understanding the relationship between aneurysm wall enhancement (AWE), wall shear stress (WSS), and wall tension (WT) across different brain aneurysm compartments may improve the assessment of rupture risk and vessel wall dynamics. Our comprehensive analysis aimed to evaluate these characteristics across different brain aneurysm compartments.

Methods: Patients with intracranial aneurysms underwent 3-T high-resolution magnetic resonance imaging (MRI).

Outcomes of Adjunct Emergent Stenting Versus Mechanical Thrombectomy Alone: The RESCUE-ICAS Registry.

Background: Underlying intracranial stenosis is the most common cause of failed mechanical thrombectomy in patients with acute ischemic stroke with large vessel occlusion. Adjunct emergent stenting is sometimes performed to improve or maintain reperfusion, despite limited data regarding its safety or efficacy.

Methods: We conducted a prospective multicenter observational international cohort study.

Semiautomated Hemorrhage Volume Quantification in Aneurysmal Subarachnoid Hemorrhage.

Background: The volume of hemorrhage is a crucial factor in predicting outcomes following aneurysmal subarachnoid hemorrhage (aSAH). Although grading scales such as the Fisher score are widely used, they can lead to inaccuracies in quantifying the total blood volume because of their reliance on visual assessment. We analyzed a large cohort of patients with aSAH with a semiautomated software for the precise quantification of hemorrhage volume.

There Is Poor Agreement between the Subjective and Quantitative Adjudication of Aneurysm Wall Enhancement.

Background And Purpose: The determination of aneurysm wall enhancement (AWE) by human readers on visual inspection alone is subjective and prone to error. A 3D method for quantifying the signal intensity (SI) of the aneurysm enables objective determination of AWE. Interreader agreement and agreement between subjective and objective determination of AWE were assessed in this study.

Radiomics-Based Predictive Nomogram for Assessing the Risk of Intracranial Aneurysms.

Aneurysm wall enhancement (AWE) has the potential to be used as an imaging biomarker for the risk stratification of intracranial aneurysms (IAs). Radiomics provides a refined approach to quantify and further characterize AWE's textural features. This study examines the performance of AWE quantification combined with clinical information in detecting symptomatic IAs.

Multicenter early United States feasibility study and periprocedural safety of LVIS EVO for the treatment of unruptured intracranial aneurysms.

Background: Stent development has focused recently on low-profile, self-expandable stents compatible with 0.0165 inch microcatheters. The LVIS EVO is the second-generation version of the Low-Profile Visualized Intraluminal Support (LVIS) with improved visibility and resheathability.

Modulation of the Immunological Milieu in Acute Aneurysmal Subarachnoid Hemorrhage: The Potential Role of Monocytes Through CXCL10 Secretion.

Emerging evidence indicates that aneurysmal subarachnoid hemorrhage (aSAH) elicits a response from both innate and adaptive immune systems. An upregulation of CD8 + CD161 + cells has been observed in the cerebrospinal fluid (CSF) after aSAH, yet the precise role of these cells in the context of aSAH is unkown. CSF samples from patients with aSAH and non-aneurysmal SAH (naSAH) were analyzed.

Radiomics-Based Predictive Nomogram for Assessing the Risk of Intracranial Aneurysms.

Background: Aneurysm wall enhancement (AWE) has the potential to be used as an imaging biomarker for the risk stratification of intracranial aneurysms (IAs). Radiomics provides a refined approach to quantify and further characterize AWE's textural features. This study examines the performance of AWE quantification combined with clinical information in detecting symptomatic IAs.