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Background: Work-related musculoskeletal disorders (WMSDs) are an emerging occupational health concern for surgeons. We studied the effect of structured exercise training, and intraoperative Targeted Stretch Micro-Breaks on surgeons' workload during open thyroidectomy and modified radical mastectomy (MRM).
Methods: Experienced surgeons performed thyroidectomies and MRM before and after a structured self-administered muscle-strengthening exercise program and Targeted Stretch Micro-Breaks. Workload was assessed using EMG, body part discomfort, and SURG-TLX questionnaires. To observe the median change in pre intervention muscle data to post intervention muscle data, Wilcoxon Sign rank test was used.
Results: Four surgeons performed 5 MRM and three thyroidectomy pre and post intervention. EMG analysis for MRM showed reduced muscle fatigue and postural muscle strain post-intervention. Thyroidectomy data indicated decreased trapezius activity, suggesting reduced neck strain. Body part discomfort questionnaire assessment showed improvement but SURG TLX didn't show any change post intervention.
Conclusions: Self-administered structured muscle-strengthening exercises and TSMB improved muscle efficiency and reduced muscle strain, although subjective workload remained unchanged.
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http://dx.doi.org/10.1016/j.amjsurg.2025.116517 | DOI Listing |
MicroPubl Biol
August 2025
Molecular, Cellular and Developmental Biology, University of Toledo, Toledo, Ohio, United States.
Cadherin-related family member 5 (CDHR5) is a protocadherin found enriched at the tips of brush border microvilli of the gut and kidney, where it plays an important role in the development of these specialized microvilli. CDHR5 is a type-1 transmembrane protein with a short cytoplasmic tail that contains a number of poly-proline motifs of unknown function. We performed an analysis of the poly-proline stretches in the CDHR5 cytoplasmic tail and show that mutation of these motifs does not largely influence the targeting of CDHR5 to microvilli, but does significantly impact the ability of the cadherin to promote microvillar elongation.
View Article and Find Full Text PDFbioRxiv
August 2025
Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA.
Proprioceptive group Ia afferents detect muscle stretch to guide effortless and purposeful movement and make monosynaptic connections with spinal α-motor neurons to mediate reflexes, such as the stretch reflex. It is thought that proprioceptive Ia afferents target motor neurons of the same spinal segment; yet, how this specificity, if any, is established during early development is unknown. Using spinal cord electrophysiology preparations from neonatal mice of both sexes, we identified a developmental period during which proprioceptive la afferents evoke both segmental and intersegmental responses at monosynaptic latencies.
View Article and Find Full Text PDFACS Nano
September 2025
Department of Biomedical Engineering, City University of Hong Kong, Kowloon Tong 999077, Hong Kong.
Acne is a common skin condition caused by the blockage of hair follicles, which is often associated with adolescents. Beyond physical discomfort and potential scarring, acne can also result in mental health issues including low self-esteem and anxiety. Among all available medical treatments, topical antibiotics are effective for acne treatment due to their rapid action, anti-inflammatory properties, minimal side effects, and accessibility.
View Article and Find Full Text PDFAdv Mind Body Med
August 2025
Professor, Symbiosis College of Nursing, Symbiosis International (Deemed University), Pune, India.
Background: Low back pain (LBP) is a prevalent issue affecting a significant portion of the global population, impacting the quality of life, especially in menopausal females.
Aim: This study aimed to assess the effectiveness of the Acharya Technique in managing LBP among late middle-aged females.
Methodology: The study used a pre-experimental research design.
ACS Chem Biol
August 2025
Department of Chemistry, University of Colorado Denver, Science Building 1151 Arapahoe Street, Denver, Colorado 80204, United States.
The use of nucleic acids as potential therapeutic tools, sensors, or biomaterials, among other applications, has dramatically increased. Among these, RNA aptamers are of interest due to an innate high specificity toward their cognate targets, which include small molecules, proteins, ions, or cells. In this work, we took advantage of the ability that 8-oxo-7,8-dihydroguanine (8-oxoG) has to participate in unique H-bonding interactions, and probed its use to increase/control the selectivity/affinity of aptamers of RNA and DNA.
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