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Purpose: No studies have validated psychiatric diseases diagnoses in Taiwan's National Health Insurance Research Database (NHIRD). We aimed to assess the interrater reliability of chart-review among psychiatrists, examine the validity of the diagnostic codes for psychotic disorders and affective diseases in the NHIRD against review-based diagnoses, and examine whether the change in the coding system from the ICD-9-CM to the ICD-10-CM affected the validity of the diagnostic codes.
Patients And Methods: The study participants were psychiatric inpatients aged 18 to 65 years who were admitted in 2015 and 2017, respectively, to the main and three branch hospitals of National Taiwan University Hospital. A chart review was conducted among 48 purposively selected inpatients with discharge diagnoses in five core categories to assess interrater reliability. This chart-review procedure was then used to generate diagnostic codes for a stratified sampling of 727 inpatients with discharge diagnoses in 12 diagnostic categories of psychotic disorders and affective disorders to examine the validity of the diagnostic codes.
Results: The intraclass correlation coefficient reliability of schizophrenia and three broad categories of diagnoses indicated good interrater reliability. The positive predictive value and sensitivity of common diagnoses in the narrow category (eg, schizophrenia) or the broad category (eg, psychotic disorders, bipolar disorders, and major depressive disorders) were high-performing (≥ 0.70), whereas those of the diagnoses of low prevalence were modest. The validity indices of claims-based diagnoses using the ICD-10-CM tended to be better than those using the ICD-9-CM.
Conclusion: This first-ever study validating psychiatric diagnoses in Taiwan's NHIRD using a structured chart review suggests that the diagnostic codes of narrow categories of schizophrenia or other broad categories are recommended for high-performing validity indices. Intensive training for the coding plus the specific details requested by the ICD-10 may increase the validity of the claims-based databases for psychotic and affective disorders.
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http://dx.doi.org/10.2147/CLEP.S522618 | DOI Listing |
J Cancer Res Clin Oncol
September 2025
Inner Mongolia Medical University Affiliated Hospital, Hohhot, 010030, Inner Mongolia, China.
Purpose: Lung cancer is currently the most common malignant tumor worldwide and one of the leading causes of cancer-related deaths, posing a serious threat to human health. MicroRNAs (miRNAs) are a class of endogenous non-coding small RNA molecules that regulate gene expression and are involved in various biological processes associated with lung cancer. Understanding the mechanisms of lung carcinogenesis and detecting disease biomarkers may enable early diagnosis of lung cancer.
View Article and Find Full Text PDFPharmacoepidemiol Drug Saf
September 2025
Sanofi, Cambridge, Massachusetts, USA.
Purpose: Given the increased likelihood for individuals with severe asthma to experience comorbidities, disease complications, emergency room visits, and hospitalizations, the ability to stratify asthma populations on severity is often important. Although pharmacoepidemiologic studies using administrative healthcare databases sometimes categorize asthma severity, there is no consensus on an approach.
Methods: Individuals with asthma (≥ 2 ICD-10-CM diagnosis codes J45) aged ≥ 6 years were identified in Optum's de-identified Clinformatics Data Mart Database between January 2017 and November 2023.
BMJ Open
September 2025
Department of Nursing, Mettu University, Mettu, Oromia, Ethiopia.
Background: Antenatal care (ANC) is a critical component for improving maternal and newborn health. It provides a platform for essential healthcare services, including health promotion, screening and diagnosis, injury and disease prevention, birth preparedness and preparation for the postnatal period. By implementing timely and appropriate evidence-based practices, ANC can reduce maternal and child morbidity and mortality and optimise overall health and well-being.
View Article and Find Full Text PDFGene
September 2025
Institute of Physiology, Medical School, University of Pécs H-7624 Pécs, Hungary. Electronic address:
In this edition of Gene's "Editor's Corner" we summarize the complex interactions of different molecular mechanisms behind the pathogenesis of neonatal hypoxic-ischemic encephalopathy (HIE). The topic is relevant, as the therapeutic options for HIE are limited, it is important to have as much knowledge as possible about the molecular processes underlying the disease. In the recent issue of Gene (Gene 952, 2025, 149363), Wang et al.
View Article and Find Full Text PDFOnline J Public Health Inform
September 2025
Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, 1225 Center Drive, Gainesville, FL, 32610, United States, 1 (352) 273-6617.
Background: TikTok became an increasingly popular platform for mental health discussions during a major global stressor (COVID-19 pandemic). On TikTok, content assumed to promote user engagement is delivered in a hyperindividually curated manner through a proprietary algorithm. Mental health providers have raised concerns about TikTok's potential role in promoting inaccurate self-diagnoses, pathologizing normal behaviors, and fostering new-onset symptoms after exposure to illness-related content, such as tic-like movements linked to conversion or factitious disorders.
View Article and Find Full Text PDF