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Medical relation extraction aims to extract pairs of entities and their corresponding relations from unstructured text, which faces the challenge of a scarcity of labeled data. Zero-shot relation extraction can extract new relations not observed during training and alleviate the problem of scarce medical data. However, existing zero-shot relation extraction methods use semantic similarity matching with limited domain representation capability. In this paper, we introduces an fied framework for zero-shot edicial elation xtraction with Large Language Models (), which leverages Large Language Models' (LLMs) advanced contextual understanding capabilities to extract relation triplets in zero-shot setting. UniMRE employs a knowledge injection strategy to infuse medical knowledge into LLMs, which enables the generation of silver labels. These labels are used to retrieve relevant samples and relation rules, which are processed by a relation extraction agent. Based on their evaluation scores, high-confidence labels are incorporated into the sample library as gold labels, while low-confidence labels are refined and regenerated based on identified errors. Extensive experiments on medical datasets demonstrate that UniMRE outperforms baseline models, validating its effectiveness in extracting structured medical knowledge.
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http://dx.doi.org/10.1007/s13755-025-00359-1 | DOI Listing |
Basic Clin Androl
September 2025
Department of Urology, University Hospital Southampton, Southampton, UK.
Background: To compare surgical and long-term patient-reported outcomes (PRO) between excisional (Nesbit) and incisional (Yachia) corporoplasty for correction of uncomplicated Peyronie's-related penile curvature in a large, single-surgeon cohort. A retrospective audit identified men who underwent Nesbit or Yachia corporoplasty (2015-2021). Operative data was extracted from records.
View Article and Find Full Text PDFBMC Womens Health
September 2025
Society for Family Health-Nigeria, Abuja, Nigeria.
Background: Interventions aimed to increase healthcare provider empathy and capacity to deliver person-centered care have been shown to improve healthcare seeking and outcomes. In the context of self-injectable contraception, empathetic counseling and coaching may be promising approaches for addressing "fear of the needle" among clients interested in using subcutaneous depot medroxyprogesterone (DMPA-SC). In Nigeria, the Delivering Innovation in Self-Care (DISC) project developed and evaluated an empathy-based in-service training and supportive supervision intervention for public sector family (FP) planning providers implemented in conjunction with community-based mobilization.
View Article and Find Full Text PDFNat Metab
September 2025
Cellular and Molecular Physiology Department, Yale School of Medicine, New Haven, CT, USA.
The essential cofactor coenzyme A (CoASH) and its thioester derivatives (acyl-CoAs) have pivotal roles in cellular metabolism. However, the mechanism by which different acyl-CoAs are accurately partitioned into different subcellular compartments to support site-specific reactions, and the physiological impact of such compartmentalization, remain poorly understood. Here, we report an optimized liquid chromatography-mass spectrometry-based pan-chain acyl-CoA extraction and profiling method that enables a robust detection of 33 cellular and 23 mitochondrial acyl-CoAs from cultured human cells.
View Article and Find Full Text PDFDiabet Med
September 2025
Endocrinology Department, East Surrey Hospital, Surrey and Sussex Healthcare NHS Trust, Redhill, UK.
Aim: To explore the experiences of patients, families and clinicians managing steroid-induced hyperglycaemia (SIH) out of the hospital and identify areas for improved care.
Methods: We searched hospital records to identify patients requiring input from the diabetes inpatient team between February 2022 and March 2023 due to steroid usage. Clinicians, patients and their family members were interviewed remotely about their experiences of care and views on how to improve it.
JMIR Res Protoc
September 2025
Division of Cancer Prevention and Control, Department of Internal Medicine, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
Background: In the United States, cancer is more prevalent in racial and ethnic minority groups and in rural-dwelling and low-income people. Compared with White people of non-Hispanic descent, Black and African American people have higher cancer mortality and Hispanic people are more likely to be diagnosed with infection-related cancers. In addition, people who live in persistent poverty areas are more vulnerable to cancer mortality.
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