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Article Abstract
Calcium ions (Ca) act as important intracellular second messengers and play a key role in cellular physiological functions and signal transduction. Ca significantly affects the biological behavior of tumor cells by regulating mechanisms, such as cytoskeleton reorganization, cell migration, invasion, and immune escape. Although research on calcium homeostasis in tumor progression and metastasis was historically limited, it has recently received widespread attention. Growing evidence indicates that the disruption of calcium homeostasis is closely linked to the development, invasion, and metastasis of tumors. This paper systematically reviews the mechanisms governing calcium homeostasis in tumor progression and metastasis. We focused on calcium channels, pumps, and their regulatory roles in ionic signaling networks, the tumor microenvironment, downstream signaling pathways, and immune escape. We also discussed therapeutic strategies targeting tumor progression and metastasis via the modulation of calcium homeostasis. By elucidating the role of calcium homeostasis in tumor metastasis, this review aims to provide a theoretical foundation and to identify potential targets for novel anti-metastatic strategies.
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| http://dx.doi.org/10.1016/j.canlet.2025.217908 | DOI Listing |
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