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Introduction: Four-Dimensional Computed Tomography (4DCT) shows promise in diagnosing scapholunate ligament (SL) lesions. Wrist motion analysis requires local coordinate systems (LCS) for carpal bones, which might be affected by bone shape variations. These variations can affect the extraction of scapholunate angle (SLA) and capitolunate angle (CLA), indicative for SL lesions. This study characterizes the impact of anatomical shape variations on LCS determination and subsequent SLA and CLA estimates.
Methods: A statistical shape model (SSM) was created for the scaphoid, lunate, and capitate using CT scans from a 4DCT dataset. The quality of the SSM was assessed using a leave-one-out approach by calculating the root mean squared error (RMSE). Subsequently, LCSs per bone were assigned to the SSM while 3000 shape variations were introduced. The rotational deviation of the LCSs was calculated by a combined rotation around the three axes. Finally, the SLAs and CLAs were calculated.
Results: The SSM was created using 106 scans with an RMSE of 0.38 mm. The 95th percentile of the rotational deviations of the LCSs was below 5°. The resulting range due to anatomical variations in the calculation of the SLA and CLA was 5.7°and 6.8°, respectively.
Conclusion: Bone shape variations have a minimal influence on the determination of LCSs and consequently on the resulting SLA and CLA estimates. Based on the naturally occurring variability of carpal angles found in literature, the ranges in the variation of the SLA and CLA are probably not clinically relevant but should be taken into account when performing inter-subject comparisons.
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http://dx.doi.org/10.1016/j.ejrad.2025.112298 | DOI Listing |
Genome Biol
September 2025
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101, Beijing, China.
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September 2025
Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.
Young-onset monogenic disorders often show variable penetrance, yet the underlying causes remain poorly understood. Uncovering these influences could reveal new biological mechanisms and enhance risk prediction for monogenic diseases. Here we show that polygenic background substantially shapes the clinical presentation of maturity-onset diabetes of the young (MODY), a common monogenic form of diabetes that typically presents in adolescence or early adulthood.
View Article and Find Full Text PDFSci Rep
September 2025
Paleoanthropology Section, Department of Geosciences, Institute for Archaeological Sciences, University of Tübingen, Tübingen, Germany.
Human communication is remarkable for its flexibility, a trait largely reflected in its multimodal nature and shared to some extent with nonhuman primates. Although individual differences in social behaviour are known to have evolutionary implications, their role in shaping primate communication remains largely unexplored. This study adopts a multimodal framework to partition variation in chimpanzees' use of multicomponent and multisensory communicative strategies into socio-environmental, between-individual, and within-individual sources.
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Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan (S.K., Y.K., Y.T.).
Rationale And Objectives: The thyroid foramen (TF) is a congenital anatomical variant of the thyroid cartilage, characterized by a small opening that may transmit neurovascular structures. Although benign, TF can be misinterpreted on imaging as a cartilage fracture or tumor invasion, and may pose a surgical risk if unrecognized. Despite these potential implications, TF remains under-recognized in routine radiological practice.
View Article and Find Full Text PDFEur J Pharm Biopharm
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Department of Chemistry, School of Natural Sciences, Faculty of Science and Engineering, The University of Manchester, Manchester M13 9PL, United Kingdom. Electronic address:
To ensure safety, pharmaceuticals are rigorously tested for lipopolysaccharide (LPS) contamination, as this can trigger severe immune reactions in patients. Low Endotoxin Recovery (LER), describing the masking of spiked LPS controls in Limulus Amebocyte Lysate (LAL) assays, has been associated with the presence of chelating agents and surfactants in pharmaceutical formulations. The addition of excipients, such as Mg2, have shown the ability to mitigate the effects of LER, however, inconsistencies in various studies regarding the influence of the excipients on LPS aggregate characteristics and LER occurrence hinder a clear understanding of the mechanisms underlying LER.
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