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Enhancing generalization capabilities and robustness in scenarios with limited sample sizes, while simultaneously decreasing reliance on extensive and high-quality datasets, represents a significant area of inquiry within the domain of radar target recognition. This study introduces a few-shot learning framework that leverages multimodal feature fusion. We develop a cross-modal representation optimization mechanism tailored for the target recognition task by incorporating natural resonance frequency features that elucidate the target's scattering characteristics. Furthermore, we establish a multimodal fusion classification network that integrates bi-directional long short-term memory and residual neural network architectures, facilitating deep bimodal fusion through an encoding-decoding framework augmented by an energy embedding strategy. To optimize the model, we propose a cross-modal equilibrium loss function that amalgamates similarity metrics from diverse features with cross-entropy loss, thereby guiding the optimization process towards enhancing metric spatial discrimination and balancing classification performance. Empirical results derived from simulated datasets indicate that the proposed methodology achieves a recognition accuracy of 95.36% in the 5-way 1-shot task, surpassing traditional unimodal image and concatenation fusion feature approaches by 2.26% and 8.73%, respectively. Additionally, the inter-class feature separation is improved by 18.37%, thereby substantiating the efficacy of the proposed method.
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http://dx.doi.org/10.3390/s25134162 | DOI Listing |
Adv Drug Deliv Rev
September 2025
Biochemistry, CUNY Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, United States; Molecular, Cellular, and Developmental Biology, CUNY Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, United States; Chemistry, CUNY Gradua
Targeted drug delivery significantly enhances therapeutic efficacy across various diseases, particularly in cancer treatments, where conventional approaches such as chemotherapy and radiotherapy often cause severe side effects. In this context, nucleic acid aptamers-short, single-stranded DNA or RNA oligonucleotides capable of binding specific targets with high affinity-have emerged as promising tools for precision drug delivery and therapy. Aptamers can be selected against whole, living cells using SELEX and chemically modified for diverse applications.
View Article and Find Full Text PDFBiomed Pharmacother
September 2025
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:
Immune-mediated necrotizing myopathy (IMNM) is an emerging and severe form of myositis. Most patients experience persistent muscle weakness or recurrent attacks within their lifetime. The previous view suggests that autoimmune and complement activation play a key role in muscle damage, and aggressive immunotherapy may benefit patients.
View Article and Find Full Text PDFAnal Chem
September 2025
Jiaxing Key Laboratory of Molecular Recognition and Sensing, College of Biological and Chemical Engineering, Jiaxing University, Jiaxing 314001, China.
Despite the promise of electrochemical biosensors in amplified nucleic acid diagnostics, existing high-sensitivity platforms often rely on a multilayer surface assembly and cascade amplification confined to the electrode interface. These stepwise strategies suffer from inefficient enzyme activity, poor mass transport, and inconsistent probe orientation, which compromise the amplification efficiency, reproducibility, and practical applicability. To address these limitations, we report a programmable dual-phase electrochemical biosensing system that decouples amplification from signal transduction.
View Article and Find Full Text PDFOphthalmol Glaucoma
September 2025
Department of Ophthalmology and Visual Sciences, University of Michigan W.K. Kellogg Eye Center, Ann Arbor, Michigan. Electronic address:
Purpose: To investigate hand function and eye drop instillation success in adults with and without glaucoma.
Design: Cross-sectional pilot study.
Subjects: Adults aged ≥ 65 years with glaucoma who use eye drops daily and adults aged 65+ without glaucoma who do not regularly use eye drops.
J Am Chem Soc
September 2025
Department of Chemistry, Boston University, 590 Commonwealth Ave, Boston, Massachusetts 02215, United States.
The cytosolic iron-sulfur cluster assembly (CIA) targeting complex maturates over 30 cytosolic and nuclear Fe-S proteins, raising the question of how a single complex recognizes such a diverse set of clients. The discovery of a C-terminal targeting complex recognition (TCR) peptide in up to 25% of CIA clients provided a clue to substrate specificity, yet the molecular and energetic basis for this interaction remained unresolved. By integrating computational and biochemical approaches, we show that the TCR peptide binds a conserved interface between the Cia1 and Cia2 subunits of the targeting complex, even in the absence of the Fe-S cluster.
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