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The macroelement (Na, Mg, P, S, K, and Ca) and microelement (Mn, Fe, Co, Cu, Zn, As, Cd, Sn, Ba, and Pb) composition of edible (arm and mantle) and non-edible (viscera) tissues of octopus () was studied. Three different size groups were considered separately (1-2, 2-3, and 3-4 kg per specimen). Additionally, the effect of cooking processing (40 min at 90 °C) and frozen storage (4 months at -18 °C) was determined. All raw tissues depicted the following increasing sequence for the macroelement content ( < 0.05): Ca < Mg < P ≈ K < Na ≈ S; regarding microelements, the raw viscera tissue showed a higher level ( < 0.05) than the counterpart edible tissues. The cooking process led to a general decrease in macroelement values ( < 0.05) in arm and mantle tissues; for microelements, no effect ( > 0.05) was observed for Co, Mn, and Sn content, but an average increase was obtained for Cd, Cu, and Pb values. The frozen storage did not lead to element content changes in the arm tissue ( > 0.05); in contrast, general content increases and decreases were detected for mantle and viscera, respectively. In spite of level changes detected, this study proves that viscera, a common waste of commercial processing, can be considered a valuable source of essential elements.
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http://dx.doi.org/10.3390/foods14132210 | DOI Listing |
Leuk Lymphoma
September 2025
Alfred Hospital and Monash University, Melbourne, Victoria, Australia.
Zanubrutinib and acalabrutinib have demonstrated efficacy in separate single-arm clinical trials in patients with relapsed/refractory (R/R) mantle cell lymphoma (MCL). Given these single-arm trials lacked a common comparator, an unanchored indirect treatment comparison was conducted to assess the comparative efficacy of zanubrutinib versus acalabrutinib using a simulated treatment comparison (STC) method. In the base case analysis (adjusted for all covariates), zanubrutinib treatment was associated with significantly improved progression-free survival (hazard ratio [HR], 0.
View Article and Find Full Text PDFNucleic Acids Res
August 2025
Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), C. Dr. Aiguader 88, Barcelona 08003, Spain.
Chromosomal translocations have largely been implicated in tumor development. However, beyond the consequences of aberrant gene expression near the breakpoint, their effects remain underexplored. In this work, we characterize the interplay between translocations, chromatin organization and gene expression using mantle cell lymphoma (MCL) as a model.
View Article and Find Full Text PDFBlood Adv
August 2025
JW Therapeutics (Shanghai) Co. Ltd, Shanghai, China., Shanghai, China.
Relma-cel, an anti-CD19 CAR-T therapy, is approved in China for R/R large B-cell lymphoma and follicular lymphoma. This phase 2, open-label, single-arm, multicenter study evaluated its efficacy and safety in Chinese patients with heavily pretreated R/R mantle cell lymphoma. A total of 70 patients with R/R MCL who had undergone 1-9 prior therapies (including anthracycline or bendamustine chemotherapy, anti-CD20 antibodies, and BTK inhibitors) were enrolled.
View Article and Find Full Text PDFEClinicalMedicine
July 2025
Department of Hematology, Chongqing Key Laboratory of Hematology and Microenvironment, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China.
Background: TP53 mutation is a critical predictor of early disease progression and poor prognosis in mantle cell lymphoma (MCL). Optimal treatment for these patients remains unclear. This systematic review and meta-analysis evaluated various strategies for achieving remission in TP53-mutated (TP53m) MCL.
View Article and Find Full Text PDFFoods
June 2025
Department of Food Technology, Marine Research Institute (CSIC), c/E. Cabello 6, 36208 Vigo, Spain.
The macroelement (Na, Mg, P, S, K, and Ca) and microelement (Mn, Fe, Co, Cu, Zn, As, Cd, Sn, Ba, and Pb) composition of edible (arm and mantle) and non-edible (viscera) tissues of octopus () was studied. Three different size groups were considered separately (1-2, 2-3, and 3-4 kg per specimen). Additionally, the effect of cooking processing (40 min at 90 °C) and frozen storage (4 months at -18 °C) was determined.
View Article and Find Full Text PDF