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Reablement is a goal-oriented rehabilitative approach designed to enhance independence, self-sufficiency, and autonomy in daily activities. This study investigated the effects of a community-based REablement-Instrumental Activities of Daily Living (RE-IADL) program on the quality of life in people with schizophrenia. Eighty people with schizophrenia were randomized into two groups: RE-IADL (n = 40) and control (n = 40). The RE-IADL group received a 6-week intervention of instrumental activities of daily living, targeting financial management, shopping, and community mobility. The control group received conventional rehabilitation. The Schizophrenia Quality of Life questionnaire (S-QoL), with eight subscales, was administered at baseline, after the six-week program, and at a three-month follow-up. Compared with the control group, the RE-IADL group showed a significant moderate immediate effect on the physical well-being subscale after the six-week program (p = 0.016, d = 0.55) and a significant moderate long-term effect on the sentimental life subscale at the three-month follow-up (p = 0.010, d = 0.59). There were no statistically significant differences between the two groups in the S-QoL index and other subscales at the six-week and three-month follow-up assessments (p = 0.057-0.966). Proportions of minimal detectable change (MDC proportion) in the S-QoL index were 13-15 % for the RE-IADL group and 3-5 % for the control group at both six weeks and three months. The MDC proportions of the subscales ranged 0-18 % and 0-5 % at six weeks and 0-13 % and 0-8 % at three months in the RE-IADL and control groups, respectively. The RE-IADL program holds promise for enhancing physical health, social participation, and emotional well-being in people with schizophrenia.
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http://dx.doi.org/10.1016/j.psychres.2025.116624 | DOI Listing |
Acta Pharmacol Sin
September 2025
Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders, Guangdong Province Key Laboratory of Psychiatric Disorders, Guangdong Bas
Recent investigations into the rapid antidepressant effects of ketamine, along with studies on schizophrenia-related susceptibility genes, have highlighted the GluN2A subunit as a critical regulator of both emotion and cognition. However, the specific impacts of acute pharmacological inhibition of GluN2A-containing NMDA receptors on brain microcircuits and the subsequent behavioral consequences remain poorly understood. In this study, we first examined the effects of MPX-004, a selective GluN2A NMDA receptor inhibitor, on behavior within the dorsomedial prefrontal cortex (dmPFC).
View Article and Find Full Text PDFJ Am Coll Cardiol
September 2025
Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region of China; Advanced Data Analytics for Medical Science Limited, Hong Kong Special Administrative Region of China
Background: There is no consensus for using statins for primary prevention of cardiovascular disease (CVD) and all-cause mortality in adults with type 1 diabetes mellitus (T1DM), because no randomized controlled trial has exclusively investigated statins in this population.
Objectives: In this study, the authors sought to evaluate the long-term risks and benefits of statins for primary prevention in adults with T1DM.
Methods: We performed a sequential target trial emulation comparing statin initiation vs noninitiation using UK primary care data from the IQVIA Medical Research Data database.
Psychopharmacology (Berl)
September 2025
Institute of Cardiovascular Research, Sleep Medical Center, Department of Psychiatry, Fundamental and Clinical Research on Mental Disorders Key Laboratory of Luzhou, Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, 646000, China.
Rationale: Genome-wide association studies (GWASs) are used to identify genetic variants for association with schizophrenia (SCZ) risk; however, each GWAS can only reveal a small fraction of this association.
Objectives: This study systematically analyzed multiple GWAS data sets to identify gene subnetwork and pathways associated with SCZ.
Methods: We identified gene subnetwork using dmGWAS program by combining SCZ GWASs and a human interaction network, performed gene-set analysis to test the association of gene subnetwork with clinical symptom scores and disease state, meanwhile, conducted spatiotemporal and tissue-specific expression patterns and cell-type-specific analysis of genes in the subnetwork.
Hum Brain Mapp
September 2025
Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, Georgia, USA.
Investigating neuroimaging data to identify brain-based markers of mental illnesses has gained significant attention. Nevertheless, these endeavors encounter challenges arising from a reliance on symptoms and self-report assessments in making an initial diagnosis. The absence of biological data to delineate nosological categories hinders the provision of additional neurobiological insights into these disorders.
View Article and Find Full Text PDFAlpha Psychiatry
August 2025
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, 610036 Chengdu, Sichuan, China.
Objective: Physical aggression in schizophrenia patients carries significant societal implications. Previous studies on aggression prediction have primarily focused on hospitalized patients, overlooking specific rural community contexts in China. This study investigated multidimensional predictive factors to develop and validate a predictive model for predicting physical aggression in schizophrenia patients in rural communities in southwestern China.
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