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Implementation and evaluation of a family planning intervention engaging mothers-in-law of young women in India: a mixed methods pilot study.
Glob Health Action
December 2025
Institute for Global Health Sciences, University of California, San Francisco, CA, USA.
Background: Despite evidence that mothers-in-law (MILs) influence daughters-in-law's (DILs) fertility and family planning decisions in South Asia, emphasizing early fertility and male grandchildren, few reproductive health interventions engage MILs directly.
Objectives: We assessed the feasibility, acceptability, and qualitative impact of a reproductive health and life skill-based intervention on MILs in tribal Rajasthan, India, using a mixed-methods, single-group cluster pilot study.
Methods: We tested a light-touch four-session intervention delivered over 4 months to MILs of newly married women that covered MILs' health, conception, and communication with DILs and sons and addressed modern healthcare misconceptions, while challenging son preference and fertility norms.
Quercetin enhances antioxidant capacity and reproductive performance in daphnia pulex.
Comp Biochem Physiol Part D Genomics Proteomics
August 2025
Freshwater Fisheries Research Institute of Jiangsu Province, 79 Chating East Street, Nanjing 210017, China. Electronic address:
Quercetin is a widely distributed flavonoid found in fruits and vegetables, known for its diverse biological effects. In this study, neonatal Daphnia pulex (within 24 h of birth) were exposed to varying concentrations of quercetin (0, 1, 2.5, 5, and 10 mg/L).
View Article and Find Full Text PDFGADD45A is Essential for Granulosa Cells Differentiation and Ovarian Reserve in Human and Mice.
J Cell Mol Med
September 2025
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
Diminished ovarian reserve (DOR) poses significant challenges in reproductive health, with emerging evidence implicating DNA damage repair pathways. While GADD45A is a critical regulator of DNA repair, cell cycle and apoptosis, its role in DOR pathogenesis remains unexplored. We employed transcriptome sequencing, qPCR and Western Blot analyses to compare GADD45A expression in granulosa cells (GCs) between DOR patients and controls.
View Article and Find Full Text PDFThis perspective serves as a primer and overview of the underlying causes of the current stress on the healthcare system, indicating no expected relief in the medium term. Demographic trends - such as ageing and growth of the population, declining birth rates, rising healthcare expenditure, and increasing workforce shortages - are presented as the context for the urgent need for greater efficiency and transformative change within the health system. Potential solutions are discussed in response to the impending crisis.
View Article and Find Full Text PDFImpact of serum progesterone level on the day of embryo transfer on live birth rate after single frozen-thawed blastocyst transfer in hormone replacement therapy cycles.
J Gynecol Obstet Hum Reprod
September 2025
Service de biologie et médecine de la reproduction, CHU de Nantes, CHU Nantes, Nantes Université, 38 Boulevard Jean Monnet, 44093, Nantes, France. Electronic address:
Purpose: As the number of frozen-thawed embryo tryansfer cycles with Hormonal Replacement Therapy increases, the issue of the optimal progesterone level to ensure maximal success rates becomes critical. In this study, we aimed to determine the respective relevance of the 3 recently reported progesterone thresholds using an original statistical method.
Methods: This single-center retrospective study was conducted in a University-based Hospital in France in all consecutive single frozen thawed blastocyst transfers (SFBT) performed with HRT protocol in 2021.