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Objective: To characterize clinical practice at a reference Oral Medicine Service (OROCENTRO) of the Piracicaba Dental School, State University of Campinas, Brazil, with an emphasis on patient medical profiles, diagnoses, diagnostic/treatment procedures, and follow-up, in order to increase the body of evidence in the literature on the scope of OM practice.
Study Design: This retrospective cross-sectional observational study followed the Declaration of Helsinki and complied with STROBE guidelines. All patients seen for the first time during a 4-year period, as well as their follow-up consultations, were included.
Results: Among 2,613 patients with 10,569 follow-up consultations (mean duration: 15.2 months; range: 0-124 months), 39.8% (n = 1,041) exhibited risk behaviors (mean: 1.2; range: 1-4), and 45% (n = 1,177) presented comorbidities (mean: 2.1; range: 1-7). A total of 235 distinct diagnoses (recorded 3,260 times) were identified, with a mean of 1.2 diagnoses per patient (range: 1-8), of which the most prevalent were fibrous hyperplasia (n = 403/12.36%) and squamous cell carcinoma (n = 147/4.51%). Additionally, 133 distinct diagnostic/treatment clinical procedures (recorded 19,861 times) were performed, with a mean of 7.6 procedures per patient (range: 1-120) over the follow-up period.
Conclusions: This study offers a comprehensive characterization of the scope of clinical practice in a reference OM service in Brazil, representing the most extensive Dental School-based analyses. It emphasizes the diversity and multifaceted nature of OM practice, contributing significantly to the broader recognition and understanding of the specialty.
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http://dx.doi.org/10.1016/j.oooo.2025.06.002 | DOI Listing |
JAMA Intern Med
September 2025
Bayer CC AG, Basel, Switzerland.
Importance: There is an unmet need for long-term, safe, effective, and hormone-free treatments for menopausal symptoms, including vasomotor symptoms (VMS) and sleep disturbances.
Objective: To evaluate the 52-week efficacy and safety of elinzanetant, a dual neurokinin-targeted therapy, for treating moderate to severe VMS associated with menopause.
Design, Setting, And Participants: OASIS-3 was a double-blind, placebo-controlled, randomized phase 3 clinical trial that was conducted at 83 sites in North America and Europe from August 27, 2021, to February 12, 2024, and included postmenopausal women aged 40 to 65 years who were seeking treatment for moderate to severe VMS (no requirement for a minimum number of VMS events per week).
JAMA Pediatr
September 2025
Department of Health Policy and Management, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Importance: For the first time in nearly 2 decades, the US infant mortality rate has increased, coinciding with a rise in overdose-related deaths as a leading cause of pregnancy-associated mortality in some states. Prematurity and low birth weight-often linked to opioid use in pregnancy-are major contributors.
Objective: To assess the health and economic impact of perinatal opioid use disorder (OUD) treatment on maternal and postpartum health, infant health in the first year of life, and infant long-term health.
JAMA Netw Open
September 2025
Division of Cardiology, Department of Internal Medicine, New Taipei Municipal TuCheng Hospital, New Taipei, Taiwan.
Importance: The cardiovascular benefits of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may vary by body mass index (BMI), but evidence on BMI-specific outcomes remains limited.
Objective: To investigate the associations of GLP-1 RA use with cardiovascular and kidney outcomes across BMI categories in patients with type 2 diabetes.
Design, Setting, And Participants: This retrospective cohort study used the Chang Gung Research Database, a clinical dataset covering multiple hospitals in Taiwan.
Int Forum Allergy Rhinol
September 2025
Department of Otolaryngology-Head and Neck Surgery, Al-Jahra Hospital, Al-Jahra, Kuwait.
Background: Various interventions have been proposed to enhance surgical field quality during endoscopic sinus surgery (ESS). This study evaluates whether preoperative oral clonidine enhances surgical field quality during ESS.
Methods: PubMed, Scopus, Web of Science, Embase, and CENTRAL databases were searched.
Cell Mol Biol (Noisy-le-grand)
September 2025
Department of Dentistry, Al-Esraa University, Baghdad, Iraq.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation and is often associated with poor oral health. Cytokines play a central role in RA immunopathogenesis. This case-control study investigated the involvement of salivary interleukin-17A (IL-17A) and interleukin-18 (IL-18) in RA patients in relation to oral health status.
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