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Formerly believed to be a subtype of odontogenic keratocyst (OKC), orthokeratinized odontogenic cyst (OOC), a rare developing odontogenic cyst, is now believed to be distinct. The clinical, radiographic, histological data are included in this report, along with a review of the literature to aid in comprehending the cyst. A retrospective search in the oral pathology department between 2018 and 2022 was conducted to recover all cases reported as OOC in SRM Dental College, Ramapuram. Radiographs and Haematoxylin and Eosin stained histological slides were re-examined. Overall, there were nine cases in which men were engaged in 80% of the instances and the group's ages varied from 20 to 35. The primary symptoms of all of the patients were pain and edema. The vast majority of cases had an impacted tooth in the jaw. All of the lesions showed clearly visible radiolucency on orthopantomographs [OPG], with the exception of one specific case. Additionally, histological examination of each patient revealed the characteristic microscopic traits and enucleation was done to treat all the cases. OOC has a more favourable outcome than OKC due to variations in prognosis, management and must be considered distinct from OKC. Most of our cases-a large majority-involved adolescent males' mandibles and involved pain and edema. Most were unilocular and all were radiolucent. The literature-recommended histopathological findings were present and all cases were enucleated.
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http://dx.doi.org/10.4103/jmau.jmau_100_23 | DOI Listing |
Acta Stomatol Croat
June 2025
Institute of Pathology, University of Zagreb, School of Medicine.
Objectives: There are two types of keratinized cystic lesions arising in the jaw - developmental cysts of odontogenic origin (odontogenic keratocyst - OKC and orthokeratinized odontogenic cyst - OOC) and epidermoid cyst (EC) of undetermined origin. These lesions have overlapping histopathological features and their treatment depends on the correct diagnosis. The aim of our study was to determine diagnostically relevant differences between these cysts and to establish criteria for diagnosing intraosseous EC.
View Article and Find Full Text PDFJ Pharm Bioallied Sci
December 2024
Department of Oral and Maxillofacial Surgery, Government Dental College and Hospital, Cuddalore, Tamil Nadu, India.
The treatment of odontogenic keratocysts (OKCs) continues to be a contentious issue in oral and maxillofacial surgery. Despite extensive research and systematic reviews, no definitive protocol or consensus has been established. This case series investigates how OKCs can be treated through a thorough approach combining preoperative investigation - fine needle aspiration cytology (FNAC) - to confirm the diagnosis of OKC, followed by treatment of the combined surgical approach of enucleation, peripheral ostectomy, and chemical cauterization using modified Carnoy's solution under local or general anesthesia.
View Article and Find Full Text PDFOrphanet J Rare Dis
March 2025
Clinic of Maxillofacial Surgery, University Hospital Brno, Jihlavska 20, Brno, Czech Republic.
Background: This retrospective study aims to evaluate the relative representation of individual types of developmental odontogenic cysts (DOCs), especially from the perspective of syndromic and non-syndromic multiple DOCs in the Czech population. In addition, we also summarize the previous studies on the occurrence of multiple DOCs and provide a literature review of case reports and case series on non-syndromic multiple DOCs, particularly dentigerous cysts (DCs) and odontogenic keratocysts (OKCs).
Methods: The study included histologically confirmed DOCs retrieved between January 1, 2012, and August 8, 2023, at the Clinic of Maxillofacial Surgery, University Hospital Brno, Czech Republic.
Cureus
January 2025
Oral and Maxillofacial Surgery, Priyadarshini Dental College and Hospital, Pandur, IND.
Orthokeratinized odontogenic cyst (OOC) is a rare developmental anomaly of the jaw, now formally recognized as a distinct entity due to its unique biological characteristics, specialized histopathological features, reduced aggressiveness, and significantly lower recurrence rate compared to odontogenic keratocysts. This report describes a case in which the cyst was surgically enucleated, and a comprehensive histopathological evaluation of the specimen confirmed the diagnosis of OOC. The report provides an in-depth exploration of the clinical management and therapeutic strategies employed in addressing this atypical and clinically significant pathological condition.
View Article and Find Full Text PDFJ Oral Pathol Med
January 2025
Department of Biochemistry, Tokyo Dental College, Chiyoda-ku, Tokyo, Japan.
Background: Odontogenic keratocyst (OKC) is a partial manifestation of Gorlin syndrome (GS), resulting from the abnormal activation of the hedgehog signaling pathway. OKC predominantly occurs in young adults and is mostly asymptomatic at the time of initial diagnosis. As OKC is asymptomatic, GS can be challenging to diagnose in certain instances.
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